Immunology of Cervical Cancer



Título del documento: Immunology of Cervical Cancer
Revista: Revista de investigación clínica
Base de datos: PERIÓDICA
Número de sistema: 000453214
ISSN: 0034-8376
Autores: 1
2
3
5
4
5
Instituciones: 1Instituto Nacional de Cancerología, Departamento de Investigación Básica, Ciudad de México. México
2Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco. México
3Universidad Nacional Autónoma de México, Instituto de Investigaciones Biomédicas, Ciudad de México. México
4Instituto Nacional de Cancerología, Departamento de Investigación Clínica, Ciudad de México. México
5Instituto Nacional de Salud Pública, Centro de Investigación en Enfermedades Infecciosas, Cuernavaca, Morelos. México
Año:
Periodo: Jul-Ago
Volumen: 72
Número: 4
Paginación: 188-197
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Optimal function of the immune system allows the recognition and elimination of infected and tumor cells. However, these cells can develop mechanisms to evade the cellular immune response. In human papillomavirus (HPV) infection, dysregulation of major histocompatibility complex Class I molecules and other components of the innate immune system promote the survival of infected cells by allowing the infection to persist which, in turn, favors the development of cancer. Further, tumor cells possess inherent mechanisms designed to block the recognition and activation of cytotoxic lymphocytes: particularly, HPV proteins such as E1 and E2 and oncoproteins E5, E6, and E7 that inhibit immune mechanisms and/or stimulate the expression of immunosuppressive cytokines. These mechanisms include a decrease in receptor activation and costimulating molecules on the surface of immune cells, as well as the constitutive expression of molecules that inhibit their function, which allow HPV persistence and tumor progression. Immunotherapy-based therapeutic options are positioned as excellent candidates for the treatment of cervical cancer
Disciplinas: Medicina
Palabras clave: Oncología,
Ginecología y obstetricia,
Inmunología,
Cáncer cervical,
Virus del papiloma humano,
Inmunoterapia,
Linfocitos T citotóxicos,
Muerte celular programada
Keyword: Oncology,
Gynecology and obstetrics,
Immunology,
Cervical cancer,
Human papillomavirus,
Cytotoxic T lymphocytes,
Programmed cell death
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