| Revue: | Quimica nova |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000313328 |
| ISSN: | 0100-4042 |
| Autores: | Fonseca, Lúbia Cristina1 Correa, Natassia Caroline Resende Garrote-Filho, Mario da Silva Cunha, Cleine Chagas da Penha-Silva, Nilson |
| Instituciones: | 1Universidade Federal de Uberlandia, Instituto de Genetica e Bioquimica, Uberlandia, Minas Gerais. Brasil |
| Año: | 2006 |
| Periodo: | Jun |
| Volumen: | 29 |
| Número: | 3 |
| Paginación: | 543-548 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | A protein presents a native (N) macro state, which is functionally active, in equilibrium with the denatured (D) macro state, which is devoid of biological activity. An ensemble of microstates forms each macrostate. The denatured state comprises a greater ensemble of microstates than the native macrostate. The N-D equilibrium can be affected by several factors, that comprise the purity of the water, temperature, pH and solute concentration. This work discusses the influence of osmolytes and chaotropics on the N-D equilibrium in aqueous solutions |
| Disciplinas: | Química |
| Palabras clave: | Bioquímica, Proteínas, Agentes caotrópicos, Estabilidad química, Osmolitos, Soluciones acuosas |
| Keyword: | Chemistry, Biochemistry, Proteins, Chaotropic agents, Chemical stability, Osmolytes, Aqueous solutions |
| Texte intégral: | Texto completo (Ver HTML) |
