| Journal: | Quimica nova |
| Database: | PERIÓDICA |
| System number: | 000313328 |
| ISSN: | 0100-4042 |
| Authors: | Fonseca, Lúbia Cristina1 Correa, Natassia Caroline Resende Garrote-Filho, Mario da Silva Cunha, Cleine Chagas da Penha-Silva, Nilson |
| Institutions: | 1Universidade Federal de Uberlandia, Instituto de Genetica e Bioquimica, Uberlandia, Minas Gerais. Brasil |
| Year: | 2006 |
| Season: | Jun |
| Volumen: | 29 |
| Number: | 3 |
| Pages: | 543-548 |
| Country: | Brasil |
| Language: | Portugués |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | A protein presents a native (N) macro state, which is functionally active, in equilibrium with the denatured (D) macro state, which is devoid of biological activity. An ensemble of microstates forms each macrostate. The denatured state comprises a greater ensemble of microstates than the native macrostate. The N-D equilibrium can be affected by several factors, that comprise the purity of the water, temperature, pH and solute concentration. This work discusses the influence of osmolytes and chaotropics on the N-D equilibrium in aqueous solutions |
| Disciplines: | Química |
| Keyword: | Bioquímica, Proteínas, Agentes caotrópicos, Estabilidad química, Osmolitos, Soluciones acuosas |
| Keyword: | Chemistry, Biochemistry, Proteins, Chaotropic agents, Chemical stability, Osmolytes, Aqueous solutions |
| Full text: | Texto completo (Ver HTML) |
