Parasitological, serological and molecular diagnosis of acute and chronic Chagas disease: from field to laboratory



Título del documento: Parasitological, serological and molecular diagnosis of acute and chronic Chagas disease: from field to laboratory
Revue: Memorias do Instituto Oswaldo Cruz
Base de datos: PERIÓDICA
Número de sistema: 000452442
ISSN: 0074-0276
Autores: 1
2
1
3
Instituciones: 1Instituto de Investigaciones en Ingeniería Genética y Biología Molecular Dr. Hector Torres, Laboratorio de Biología Molecular de la Enfermedad de Chagas, Buenos Aires. Argentina
2Universidad de Barcelona, Hospital Clínico, Barcelona. España
3Foundation for Innovative New Diagnostics, Ginebra. Suiza
Año:
Volumen: 117
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés There is no consensus on the diagnostic algorithms for many scenarios of Trypanosoma cruzi infection, which hinders the establishment of governmental guidelines in endemic and non-endemic countries. In the acute phase, parasitological methods are currently employed, and standardised surrogate molecular tests are being introduced to provide higher sensitivity and less operator-dependence. In the chronic phase, IgG-based serological assays are currently used, but if a single assay does not reach the required accuracy, PAHO/WHO recommends at least two immunological tests with different technical principles. Specific algorithms are applied to diagnose congenital infection, screen blood and organ donors or conduct epidemiological surveys. Detecting Chagas disease reactivation in immunosuppressed individuals is an area of increasing interest. Due to its neglect, enhancing access to diagnosis of patients at risk of suffering T. cruzi infection should be a priority at national and regional levels
Disciplinas: Medicina
Palabras clave: Parasitología,
Diagnóstico,
Enfermedad de Chagas,
Diagnóstico molecular,
Reacción en cadena de la polimerasa (PCR),
Amplificación isotérmica
Keyword: Parasitology,
Diagnosis,
Chagas disease,
Molecular diagnosis,
Polymerase chain reaction (PCR),
Isothermal amplification
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