| Journal: | Memorias do Instituto Oswaldo Cruz |
| Database: | PERIÓDICA |
| System number: | 000452442 |
| ISSN: | 0074-0276 |
| Authors: | Schijman, Alejandro Gabriel1 Alonso Padilla, Julio2 Longhi, Silvia Andrea1 Picado, Albert3 |
| Institutions: | 1Instituto de Investigaciones en Ingeniería Genética y Biología Molecular Dr. Hector Torres, Laboratorio de Biología Molecular de la Enfermedad de Chagas, Buenos Aires. Argentina 2Universidad de Barcelona, Hospital Clínico, Barcelona. España 3Foundation for Innovative New Diagnostics, Ginebra. Suiza |
| Year: | 2022 |
| Volumen: | 117 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | There is no consensus on the diagnostic algorithms for many scenarios of Trypanosoma cruzi infection, which hinders the establishment of governmental guidelines in endemic and non-endemic countries. In the acute phase, parasitological methods are currently employed, and standardised surrogate molecular tests are being introduced to provide higher sensitivity and less operator-dependence. In the chronic phase, IgG-based serological assays are currently used, but if a single assay does not reach the required accuracy, PAHO/WHO recommends at least two immunological tests with different technical principles. Specific algorithms are applied to diagnose congenital infection, screen blood and organ donors or conduct epidemiological surveys. Detecting Chagas disease reactivation in immunosuppressed individuals is an area of increasing interest. Due to its neglect, enhancing access to diagnosis of patients at risk of suffering T. cruzi infection should be a priority at national and regional levels |
| Disciplines: | Medicina |
| Keyword: | Parasitología, Diagnóstico, Enfermedad de Chagas, Diagnóstico molecular, Reacción en cadena de la polimerasa (PCR), Amplificación isotérmica |
| Keyword: | Parasitology, Diagnosis, Chagas disease, Molecular diagnosis, Polymerase chain reaction (PCR), Isothermal amplification |
| Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
