Simultaneous determination of paracetamol, dextromethorphan, chlorpheniramine, pseudoephedrine and major impurities of paracetamol and pseudoephedrine by using capillary electrophoresis
Título del documento: Simultaneous determination of paracetamol, dextromethorphan, chlorpheniramine, pseudoephedrine and major impurities of paracetamol and pseudoephedrine by using capillary electrophoresis
Revue: Brazilian Journal of Pharmaceutical Sciences
Base de datos: PERIÓDICA
Número de sistema: 000451909
ISSN: 1984-8250
Autores: 1
2
2
1
Instituciones: 1Gazi University, Faculty of Pharmacy, Ankara. Turquía
2Ankara University, Faculty of Pharmacy, Ankara. Turquía
Año:
Volumen: 58
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés A capillary electrophoresis method was developed for the first time and optimized for the determination of paracetamol, pseudoephedrine, dextromethorphan, chlorpheniramine, 4-aminophenol and ephedrine in tablet formulation. Optimum electrophoretic conditions were achieved by using a background electrolyte of 75 mmol L-1 sodium borate buffer at pH 8.0, a capillary temperature of 30°C, a separation voltage of 30 kV and a pressure injection of the sample at 50 mbar for 10 s. Calibration graphs showed a good linearity with a coefficient of determination (R2) of at least 0.999 for all compounds. Intraday and interday precision (expressed as relative standard deviation (RSD) %) were lower than 1.39% for capillary electrophoresis method. The developed method was demonstrated to be simple and rapid for the determination of paracetamol, pseudoephedrine, dextromethorphan, chlorpheniramine, 4-aminophenol and ephedrine in tablet formulation providing recoveries in the range between 99.62 and 100.57% for all analytes
Disciplinas: Química
Palabras clave: Química farmacéutica,
Química analítica,
Electroforesis por capilaridad,
Clorfeniramina,
Dextrometorfano,
Paracetamol,
Pseudoefedrina
Keyword: Medicinal chemistry,
Analytical chemistry,
Capillary electrophoresis,
Chlorpheniramine,
Dextromethorphan,
Paracetamol,
Pseudoephedrine
Texte intégral: Texto completo (Ver HTML) Texto completo (Ver PDF)