| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451909 |
| ISSN: | 1984-8250 |
| Authors: | Yener, Beytul1 Erkmen, Cem2 Uslu, Bengi2 Goger, Nilgun Gunden1 |
| Institutions: | 1Gazi University, Faculty of Pharmacy, Ankara. Turquía 2Ankara University, Faculty of Pharmacy, Ankara. Turquía |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | A capillary electrophoresis method was developed for the first time and optimized for the determination of paracetamol, pseudoephedrine, dextromethorphan, chlorpheniramine, 4-aminophenol and ephedrine in tablet formulation. Optimum electrophoretic conditions were achieved by using a background electrolyte of 75 mmol L-1 sodium borate buffer at pH 8.0, a capillary temperature of 30°C, a separation voltage of 30 kV and a pressure injection of the sample at 50 mbar for 10 s. Calibration graphs showed a good linearity with a coefficient of determination (R2) of at least 0.999 for all compounds. Intraday and interday precision (expressed as relative standard deviation (RSD) %) were lower than 1.39% for capillary electrophoresis method. The developed method was demonstrated to be simple and rapid for the determination of paracetamol, pseudoephedrine, dextromethorphan, chlorpheniramine, 4-aminophenol and ephedrine in tablet formulation providing recoveries in the range between 99.62 and 100.57% for all analytes |
| Disciplines: | Química |
| Keyword: | Química farmacéutica, Química analítica, Electroforesis por capilaridad, Clorfeniramina, Dextrometorfano, Paracetamol, Pseudoefedrina |
| Keyword: | Medicinal chemistry, Analytical chemistry, Capillary electrophoresis, Chlorpheniramine, Dextromethorphan, Paracetamol, Pseudoephedrine |
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