Revue: | Brazilian Journal of Pharmaceutical Sciences |
Base de datos: | PERIÓDICA |
Número de sistema: | 000451960 |
ISSN: | 1984-8250 |
Autores: | Jahanshahi, Mehrdad1 Khalili, Masoumeh1 Margdari, Asra1 Aalikhani, Mahdi3 |
Instituciones: | 1Golestan University of Medical Sciences, Neuroscience Research Center, Gorgan, Golestan. Irán 2Golestan University of Medical Sciences, School of Advanced Technologies in Medicine, Gorgan, Golestan. Irán |
Año: | 2022 |
Volumen: | 58 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Experimental, aplicado |
Resumen en inglés | Naringin has been shown to exhibit satisfying iron chelation capacity. Considering the side effects of routinely-used iron chelator (desferrioxamine, DFO), we decided to evaluate the iron chelation potency of naringin to discover whether or not it can be a promising natural substitute for treatment of excessive iron-related diseases. 35 mice were classified into five groups of 7 and subjected to iron dextran administration to induce the iron-overload condition. Iron-overloaded mice were then treated with normal saline (as control), naringin or DFO Morphology changes, and iron deposition in liver tissues were studied using H&E and Perl’s staining. The results revealed that naringin is more potent than DFO in removing excessive iron ions deposited in liver tissues, indicating that naringin is a promising natural compound for therapy of iron overload disorders |
Disciplinas: | Medicina, Química |
Palabras clave: | Metabolismo y nutrición, Farmacología, Medicina experimental, Metabolismo de hierro, Sobrecarga de hierro, Naringina, Quelación, Deferoxamina, Ratones |
Keyword: | Metabolism and nutrition, Pharmacology, Experimental medicine, Iron metabolism, Iron overload, Chelation, Naringin, Deferoxamine, Mice |
Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |