Naringin is a promising natural compound for therapy of iron-overload disorders
Document title: Naringin is a promising natural compound for therapy of iron-overload disorders
Journal: Brazilian Journal of Pharmaceutical Sciences
Database: PERIÓDICA
System number: 000451960
ISSN: 1984-8250
Authors: 1
1
1
3
Institutions: 1Golestan University of Medical Sciences, Neuroscience Research Center, Gorgan, Golestan. Irán
2Golestan University of Medical Sciences, School of Advanced Technologies in Medicine, Gorgan, Golestan. Irán
Year:
Volumen: 58
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Naringin has been shown to exhibit satisfying iron chelation capacity. Considering the side effects of routinely-used iron chelator (desferrioxamine, DFO), we decided to evaluate the iron chelation potency of naringin to discover whether or not it can be a promising natural substitute for treatment of excessive iron-related diseases. 35 mice were classified into five groups of 7 and subjected to iron dextran administration to induce the iron-overload condition. Iron-overloaded mice were then treated with normal saline (as control), naringin or DFO Morphology changes, and iron deposition in liver tissues were studied using H&E and Perl’s staining. The results revealed that naringin is more potent than DFO in removing excessive iron ions deposited in liver tissues, indicating that naringin is a promising natural compound for therapy of iron overload disorders
Disciplines: Medicina,
Química
Keyword: Metabolismo y nutrición,
Farmacología,
Medicina experimental,
Metabolismo de hierro,
Sobrecarga de hierro,
Naringina,
Quelación,
Deferoxamina,
Ratones
Keyword: Metabolism and nutrition,
Pharmacology,
Experimental medicine,
Iron metabolism,
Iron overload,
Chelation,
Naringin,
Deferoxamine,
Mice
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