Revue: | Brazilian Journal of Pharmaceutical Sciences |
Base de datos: | PERIÓDICA |
Número de sistema: | 000451730 |
ISSN: | 1984-8250 |
Autores: | Akman, Tugrul Cagri1 Kadioglu, Yucel2 Senol, Onur2 Erkayman, Beyzagul2 |
Instituciones: | 1Erzincan Binali Yildirim University, Faculty of Pharmacy, Erzincan. Turquía 2Ataturk University, Faculty of Pharmacy, Erzurum. Turquía |
Año: | 2022 |
Volumen: | 58 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Experimental, aplicado |
Resumen en inglés | Changes in metabolite levels of patients using the long-term drug can be comprehensively demonstrated by pharmacometabolomic studies. In this study, biological alterations induced by the administration of solifenacin succinate were investigated with a pharmacometabolomics approach on rat metabolism. Plasma samples obtained from rats were analyzed by LC-Q- TOF/MS/MS. METLIN and HMDB databases were used to identify metabolites. Data were processed and classified with MATLAB 2017b. 53 m/z values were found to be significantly different between the drug and control groups (p ≤ 0.01 and fold analysis > 1.5) and identified by comparing METLIN and HMDB databases. According to multivariate data analysis, changes in arachidonic acid, thromboxane A2, palmitic acid, choline, calcitriol, histamine phosphate, retinyl ester, l-cysteine, l-leucine, beta-alanine, l-histidine levels were found to be statistically significant compare to the control group. Differences in the biosynthesis of phenylalanine, aminoacyl-tRNA, tyrosine, tryptophan, metabolism of glycerophospholipid, cysteine, methionine, histidine, arachidonic metabolism have been successfully demonstrated by the metabolomics approach. Our study provides important information to explain the efficacy and toxicity of chronic administration of solifenacin succinate |
Disciplinas: | Medicina, Química |
Palabras clave: | Farmacología, Medicina experimental, Metabolómica, Succinato de solifenacina, Modelos animales, Ratas |
Keyword: | Pharmacology, Experimental medicine, Metabolomics, Solifenacin succinate, Animal models, Rats |
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