Metabolomics approach: Interpretation of changes in rat plasma metabolites after solifenacin treatment
Document title: Metabolomics approach: Interpretation of changes in rat plasma metabolites after solifenacin treatment
Journal: Brazilian Journal of Pharmaceutical Sciences
Database: PERIÓDICA
System number: 000451730
ISSN: 1984-8250
Authors: 1
2
2
2
Institutions: 1Erzincan Binali Yildirim University, Faculty of Pharmacy, Erzincan. Turquía
2Ataturk University, Faculty of Pharmacy, Erzurum. Turquía
Year:
Volumen: 58
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Changes in metabolite levels of patients using the long-term drug can be comprehensively demonstrated by pharmacometabolomic studies. In this study, biological alterations induced by the administration of solifenacin succinate were investigated with a pharmacometabolomics approach on rat metabolism. Plasma samples obtained from rats were analyzed by LC-Q- TOF/MS/MS. METLIN and HMDB databases were used to identify metabolites. Data were processed and classified with MATLAB 2017b. 53 m/z values were found to be significantly different between the drug and control groups (p ≤ 0.01 and fold analysis > 1.5) and identified by comparing METLIN and HMDB databases. According to multivariate data analysis, changes in arachidonic acid, thromboxane A2, palmitic acid, choline, calcitriol, histamine phosphate, retinyl ester, l-cysteine, l-leucine, beta-alanine, l-histidine levels were found to be statistically significant compare to the control group. Differences in the biosynthesis of phenylalanine, aminoacyl-tRNA, tyrosine, tryptophan, metabolism of glycerophospholipid, cysteine, methionine, histidine, arachidonic metabolism have been successfully demonstrated by the metabolomics approach. Our study provides important information to explain the efficacy and toxicity of chronic administration of solifenacin succinate
Disciplines: Medicina,
Química
Keyword: Farmacología,
Medicina experimental,
Metabolómica,
Succinato de solifenacina,
Modelos animales,
Ratas
Keyword: Pharmacology,
Experimental medicine,
Metabolomics,
Solifenacin succinate,
Animal models,
Rats
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