| Revue: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451680 |
| ISSN: | 1984-8250 |
| Autores: | Hassanpour, Rezvan1 Chizari, Atieh2 Bayat, Amir Hossein3 Azizbeigi, Ronak4 Mahmoudi, Maedeh5 Mousavi, Zahra2 Haghparast, Abbas5 |
| Instituciones: | 1Shahid Beheshti University of Medical Sciences, School of Pharmacy, Teherán. Irán 2Islamic Azad University, Tehran Medical Sciences, Teherán. Irán 3Saveh University of Medical Sciences, Department of Neuroscience & Psychiatry, Saveh. Irán 4Islamic Azad University, Sanandaj Branch, Sanandaj. Irán 5Shahid Beheshti University of Medical Sciences, Neuroscience Research Center, Teherán. Irán |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Insulin receptors have distributed in all brain regions, including the nucleus Accumbens (NAc), and where is implicated in the reward properties of drugs. It is well known that insulin signaling can regulate dopamine release. Therefore, in the present study, we tried to examine the effect of insulin replacement on the acquisition and expression of morphine-induced conditioned place preference (CPP) in diabetic rats. Forty-eight male Wistar rats were divided into two non-diabetic (Naïve) and diabetic groups rendered by a single injection of streptozotocin (STZ). These groups separately received insulin (10U/kg) or saline (1 ml/kg) one hour prior to morphine administration (5mg/kg;s.c.) during conditioning days (acquisition phase) or post-conditioning day (expression phase) in the CPP paradigm. In this paradigm, conditioning score (CS) and locomotion activity were recorded by Ethovision. The STZ-induced diabetic rats displayed higher CS compared to naïve rats (P<0.05). This effect was abolished in all diabetic rats that received insulin during conditioning days but not the expression phase. This study has provided evidence that insulin plays a modulatory role in morphine-induced CPP, and insulin replacement during the acquisition phase could reduce the rewarding properties of morphine in diabetes conditions through a possible modulating effect on dopamine release in the NAc region |
| Disciplinas: | Medicina |
| Palabras clave: | Medicina experimental, Farmacología, Diabetes, Neuroendocrinología, Insulina, Diabetes, Receptores químicos, Morfina, Etología, Ratas |
| Keyword: | Experimental medicine, Pharmacology, Diabetes, Neuroendocrinology, Insulin, Chemical receptors, Morphine, Ethology, Rats |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
