Insulin replacement prevents the acquisition but not the expression of morphine-induced conditioned place preference in streptozotocin-induced diabetic rats
Document title: Insulin replacement prevents the acquisition but not the expression of morphine-induced conditioned place preference in streptozotocin-induced diabetic rats
Journal: Brazilian Journal of Pharmaceutical Sciences
Database: PERIÓDICA
System number: 000451680
ISSN: 1984-8250
Authors: 1
2
3
4
5
2
5
Institutions: 1Shahid Beheshti University of Medical Sciences, School of Pharmacy, Teherán. Irán
2Islamic Azad University, Tehran Medical Sciences, Teherán. Irán
3Saveh University of Medical Sciences, Department of Neuroscience & Psychiatry, Saveh. Irán
4Islamic Azad University, Sanandaj Branch, Sanandaj. Irán
5Shahid Beheshti University of Medical Sciences, Neuroscience Research Center, Teherán. Irán
Year:
Volumen: 58
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Insulin receptors have distributed in all brain regions, including the nucleus Accumbens (NAc), and where is implicated in the reward properties of drugs. It is well known that insulin signaling can regulate dopamine release. Therefore, in the present study, we tried to examine the effect of insulin replacement on the acquisition and expression of morphine-induced conditioned place preference (CPP) in diabetic rats. Forty-eight male Wistar rats were divided into two non-diabetic (Naïve) and diabetic groups rendered by a single injection of streptozotocin (STZ). These groups separately received insulin (10U/kg) or saline (1 ml/kg) one hour prior to morphine administration (5mg/kg;s.c.) during conditioning days (acquisition phase) or post-conditioning day (expression phase) in the CPP paradigm. In this paradigm, conditioning score (CS) and locomotion activity were recorded by Ethovision. The STZ-induced diabetic rats displayed higher CS compared to naïve rats (P<0.05). This effect was abolished in all diabetic rats that received insulin during conditioning days but not the expression phase. This study has provided evidence that insulin plays a modulatory role in morphine-induced CPP, and insulin replacement during the acquisition phase could reduce the rewarding properties of morphine in diabetes conditions through a possible modulating effect on dopamine release in the NAc region
Disciplines: Medicina
Keyword: Medicina experimental,
Farmacología,
Diabetes,
Neuroendocrinología,
Insulina,
Diabetes,
Receptores químicos,
Morfina,
Etología,
Ratas
Keyword: Experimental medicine,
Pharmacology,
Diabetes,
Neuroendocrinology,
Insulin,
Chemical receptors,
Morphine,
Ethology,
Rats
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