| Revue: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000450975 |
| ISSN: | 1984-8250 |
| Autores: | Tej, Rabeb1 Hamdi, Amel1 Serairi Beji, Raja2 Aidi Wannes, Wissem2 Bettaieb Rebey, Iness2 Oueslati, Samia2 Ksouri, Riadh2 Saidani Tounsi, Moufida2 Lachaal, Mokhtar1 Karray Bouraoui, Najoua1 |
| Instituciones: | 1Faculte des Sciences de Tunis, Unite de Physiologie et de Biochimie de la Reponse des Plantes aux Contraintes Abiotiques, El Manar. Túnez 2Center of Biotechnology of the Technopole Borj-Cedria, Laboratory of Aromatic and Medicinal Plants, Hammam-Lif. Túnez |
| Año: | 2019 |
| Volumen: | 55 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | The purpose of the present investigation is to assess, for the first time, the antidiabetic, antihyperlipidemic and antioxidant activities of Lycium europaeum extract in alloxan-induced diabetic rats. Diabetes was induced in adult male Wistar rats via a single subcutaneous alloxan injection (120 mg/kg). Lycium europaeum aqueous extract was orally administered at a dose of 20 mg/kg for 28 consecutive days. Serum concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) were assayed at the end of the experimental period in all investigated groups. Antioxidant enzymes such as glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) were sought in the serum and pancreas. Lycium europaeum extract significantly increased HDL-C and reduced blood glucose, TC, LDL-C and TG as compared to the alloxan-control group. Lycium europaeum extract was also efficient in reducing oxidative stress in diabetic rats by increasing SOD, CAT and GPx activities both in the pancreas and the plasma of the animals. Moreover, Lycium europaeum extract contained considerable levels of polyphenols and flavonoids. It also exhibited an important antioxidant capacity and a remarkable ability to quench DPPH radicals and reduce irons. The obtained results highlight potentially relevant health beneficial effects of Lycium europaeum extract, reversing hyperglycemic, hyperlipidemic and oxidative stress effects in rats with alloxan-induced diabetes. Therefore, it may be considered as a promising alternative or complementary agent to diabetes treatment |
| Disciplinas: | Química |
| Palabras clave: | Fitoquímica, Extracto de hoja, Actividad biológica, Antihiperglucemiantes, Antihiperlipidémicos, Actividad antioxidante, Diabetes, Lycium europaeum, Solanaceae |
| Keyword: | Phytochemistry, Leaf extract, Biological activity, Antihyperglycemiant, Antihyperlipidemics, Antioxidant activity, Diabetes, Lycium europaeum, Solanaceae |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
