Does Lycium europaeum leaf have antihyperglycemic, antihyperlipidemic and antioxidant effects
Document title: Does Lycium europaeum leaf have antihyperglycemic, antihyperlipidemic and antioxidant effects
Journal: Brazilian Journal of Pharmaceutical Sciences
Database: PERIÓDICA
System number: 000450975
ISSN: 1984-8250
Authors: 1
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2
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Institutions: 1Faculte des Sciences de Tunis, Unite de Physiologie et de Biochimie de la Reponse des Plantes aux Contraintes Abiotiques, El Manar. Túnez
2Center of Biotechnology of the Technopole Borj-Cedria, Laboratory of Aromatic and Medicinal Plants, Hammam-Lif. Túnez
Year:
Volumen: 55
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract The purpose of the present investigation is to assess, for the first time, the antidiabetic, antihyperlipidemic and antioxidant activities of Lycium europaeum extract in alloxan-induced diabetic rats. Diabetes was induced in adult male Wistar rats via a single subcutaneous alloxan injection (120 mg/kg). Lycium europaeum aqueous extract was orally administered at a dose of 20 mg/kg for 28 consecutive days. Serum concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) were assayed at the end of the experimental period in all investigated groups. Antioxidant enzymes such as glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) were sought in the serum and pancreas. Lycium europaeum extract significantly increased HDL-C and reduced blood glucose, TC, LDL-C and TG as compared to the alloxan-control group. Lycium europaeum extract was also efficient in reducing oxidative stress in diabetic rats by increasing SOD, CAT and GPx activities both in the pancreas and the plasma of the animals. Moreover, Lycium europaeum extract contained considerable levels of polyphenols and flavonoids. It also exhibited an important antioxidant capacity and a remarkable ability to quench DPPH radicals and reduce irons. The obtained results highlight potentially relevant health beneficial effects of Lycium europaeum extract, reversing hyperglycemic, hyperlipidemic and oxidative stress effects in rats with alloxan-induced diabetes. Therefore, it may be considered as a promising alternative or complementary agent to diabetes treatment
Disciplines: Química
Keyword: Fitoquímica,
Extracto de hoja,
Actividad biológica,
Antihiperglucemiantes,
Antihiperlipidémicos,
Actividad antioxidante,
Diabetes,
Lycium europaeum,
Solanaceae
Keyword: Phytochemistry,
Leaf extract,
Biological activity,
Antihyperglycemiant,
Antihyperlipidemics,
Antioxidant activity,
Diabetes,
Lycium europaeum,
Solanaceae
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