Revue: | Brazilian Journal of Pharmaceutical Sciences |
Base de datos: | PERIÓDICA |
Número de sistema: | 000451440 |
ISSN: | 1984-8250 |
Autores: | Fernandes, Amanda Velinna1 Pydi, Chinna Raja1 Verma, Ruchi1 Jose, Jobin2 Kumar, Lalit1 |
Instituciones: | 1Manipal Academy of Higher Education, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka. India 2NITTE Deemed to be University, NGSM Institute of Pharmaceutical Sciences, Deralakatte, Mangalore. India |
Año: | 2020 |
Volumen: | 56 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Experimental, aplicado |
Resumen en inglés | Present study was aimed to prepare and characterize fluconazole loaded nanostructured lipid carriers (FLZ-NLCs) for the treatment of fungal infections. Fungal infections are tremendously widespread and are the often faced dermatological condition worldwide. FLZ-NLCs was prepared by ultrasonication emulsion technique using stearic acid (SA) as solid lipid, castor oil as liquid lipid and tween 20 as a surfactant. The mean diameter of optimized FLZ-NLCs were found to be 359.15 ± 9.83 nm. The drug content and entrapment efficiency of NLCs was found to be 102.97 ± 7.45% and 87 ± 0.59%, respectively. In vitro drug release studies of FLZ-NLCs showed 37.34 ± 2.08% drug release over a period of 72 h. The above studies confirmed the prepared FLZ-NLCs may be useful for the treatment of fungal infections |
Disciplinas: | Química |
Palabras clave: | Química farmacéutica, Fluconazol, Acarreadores, Lípidos, Diseño factorial |
Keyword: | Medicinal chemistry, Fluconazole, Carriers, Lipids, Factorial design |
Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |