Design, preparation and in vitro characterizations of fluconazole loaded nanostructured lipid carriers
Document title: Design, preparation and in vitro characterizations of fluconazole loaded nanostructured lipid carriers
Journal: Brazilian Journal of Pharmaceutical Sciences
Database: PERIÓDICA
System number: 000451440
ISSN: 1984-8250
Authors: 1
1
1
2
1
Institutions: 1Manipal Academy of Higher Education, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka. India
2NITTE Deemed to be University, NGSM Institute of Pharmaceutical Sciences, Deralakatte, Mangalore. India
Year:
Volumen: 56
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Present study was aimed to prepare and characterize fluconazole loaded nanostructured lipid carriers (FLZ-NLCs) for the treatment of fungal infections. Fungal infections are tremendously widespread and are the often faced dermatological condition worldwide. FLZ-NLCs was prepared by ultrasonication emulsion technique using stearic acid (SA) as solid lipid, castor oil as liquid lipid and tween 20 as a surfactant. The mean diameter of optimized FLZ-NLCs were found to be 359.15 ± 9.83 nm. The drug content and entrapment efficiency of NLCs was found to be 102.97 ± 7.45% and 87 ± 0.59%, respectively. In vitro drug release studies of FLZ-NLCs showed 37.34 ± 2.08% drug release over a period of 72 h. The above studies confirmed the prepared FLZ-NLCs may be useful for the treatment of fungal infections
Disciplines: Química
Keyword: Química farmacéutica,
Fluconazol,
Acarreadores,
Lípidos,
Diseño factorial
Keyword: Medicinal chemistry,
Fluconazole,
Carriers,
Lipids,
Factorial design
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