| Revue: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452217 |
| ISSN: | 1984-8250 |
| Autores: | Khan, Sadia1 Kazmi, Mehdi Hassan1 Fatima, Itrat2 Malik, Abdul2 Inamullah, Farah1 Farheen, Sadia3 Abbas, Tanveer4 |
| Instituciones: | 1University of Karachi, Department of Applied Chemistry, Karachi, Baluchistán. Pakistán 2University of Karachi, International Centre for Chemical and Biological Sciences, Karachi, Baluchistán. Pakistán 3PCSIR Laboratories Complex Karachi, Pharmaceutical Research Centre, Karachi, Baluchistán. Pakistán 4University of Karachi, Department of Microbiology, Karachi, Baluchistán. Pakistán |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Cashmirins A (1) and B (2), new prenylated coumarins, have been isolated from the EtOAc- soluble fraction of the whole plant of Sorbus cashmiriana Hedlung, Monog. along with seselin (3), scopoletin (4), 3-hydroxyxanthyletin (5) and luteolin (6), reported for the first time from this species. Their structures were elucidated by spectroscopic techniques including MS, 1D and 2D NMR spectroscopy. Both new compounds 1 and 2 were investigated for biological activities and showed significant antifungal and urease inhibitory activities. Compounds 1 and 2 exhibited significant activity against Aspergillus flavus, Macrophomina phaseolina, Trichophyton simii, Trichophyton schoenleinii, and Pseudallescheria boydri. Both compounds also exhibited significant inhibitory activity against Jack bean urease with IC50 values of 28.2±0.12 µM and 30.3±0.18 µM, respectively compared to thiourea used as positive control |
| Disciplinas: | Química |
| Palabras clave: | Fitoquímica, Farmacología, Cumarinas, Cashmirina, Actividad antifúngica, Sorbus cashmiriana, Rosaceae |
| Keyword: | Phytochemistry, Pharmacology, Coumarins, Cashmirin, Antifungal activity, Sorbus cashmiriana, Rosaceae |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
