Cashmirins A and B, new antifungal and urease inhibitory prenylated coumarins from Sorbus cashmiriana
Document title: Cashmirins A and B, new antifungal and urease inhibitory prenylated coumarins from Sorbus cashmiriana
Journal: Brazilian Journal of Pharmaceutical Sciences
Database: PERIÓDICA
System number: 000452217
ISSN: 1984-8250
Authors: 1
1
2
2
1
3
4
Institutions: 1University of Karachi, Department of Applied Chemistry, Karachi, Baluchistán. Pakistán
2University of Karachi, International Centre for Chemical and Biological Sciences, Karachi, Baluchistán. Pakistán
3PCSIR Laboratories Complex Karachi, Pharmaceutical Research Centre, Karachi, Baluchistán. Pakistán
4University of Karachi, Department of Microbiology, Karachi, Baluchistán. Pakistán
Year:
Volumen: 58
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Cashmirins A (1) and B (2), new prenylated coumarins, have been isolated from the EtOAc- soluble fraction of the whole plant of Sorbus cashmiriana Hedlung, Monog. along with seselin (3), scopoletin (4), 3-hydroxyxanthyletin (5) and luteolin (6), reported for the first time from this species. Their structures were elucidated by spectroscopic techniques including MS, 1D and 2D NMR spectroscopy. Both new compounds 1 and 2 were investigated for biological activities and showed significant antifungal and urease inhibitory activities. Compounds 1 and 2 exhibited significant activity against Aspergillus flavus, Macrophomina phaseolina, Trichophyton simii, Trichophyton schoenleinii, and Pseudallescheria boydri. Both compounds also exhibited significant inhibitory activity against Jack bean urease with IC50 values of 28.2±0.12 µM and 30.3±0.18 µM, respectively compared to thiourea used as positive control
Disciplines: Química
Keyword: Fitoquímica,
Farmacología,
Cumarinas,
Cashmirina,
Actividad antifúngica,
Sorbus cashmiriana,
Rosaceae
Keyword: Phytochemistry,
Pharmacology,
Coumarins,
Cashmirin,
Antifungal activity,
Sorbus cashmiriana,
Rosaceae
Full text: Texto completo (Ver HTML) Texto completo (Ver PDF)