| Revue: | Avances en biomedicina |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000379323 |
| ISSN: | 2244-7881 |
| Autores: | Vielma, Silvana1 |
| Instituciones: | 1Universidad de Los Andes, Facultad de Medicina, Mérida. Venezuela |
| Año: | 2013 |
| Periodo: | Oct |
| Volumen: | 2 |
| Paginación: | 48-48 |
| País: | Venezuela |
| Idioma: | Inglés |
| Tipo de documento: | Resúmenes |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Several mechanisms have been proposed to explain the pathogenesis of dengue virus (DENV) infection. One of the most important finding is the production of pro-inflammatory cytokines as responsible of endothelial cells activation, plasma leakage and subsequently, disease severity. Methods: Our aim was to determined levels of inflammatory mediators (IL-8, TNF-α), soluble cell adhesion molecules (sICAM-1 and sVCAM-1) and soluble lymphocyte activation markers (sIL-2Rα, sTNF-RII/p75) during the course of DENV infection. Serum samples from fifty-two patients with confirmed DENV infection were collected during the acute (0-3 days after fever onset) and critical/recovery (4-7 days after onset) phases of the diseases. As controls, sera from non-febrile individuals were included. Patients were classified as dengue without warning signs (DwoWS), dengue with warning signs (DwWS) and severe dengue (SD). Results: Levels of sIL-8 and sTNF-α were significant higher in cases of DwWS during the critical phase of the disease. A significant increase of sICAM-1 and sVCAM-1 were detected during the critical phase of the disease compare with controls, however, the highest levels of sVCAM-1 were observed during the acute phase of SD. Finally, sIL2-R showed a significantly increased during the acute phases of SD, while sTNF-RII/p75 was elevated in DwWS during the critical stage of infection. Conclusion: sIL2-R and sVCAM-1 may be early markers of lymphocyte and endothelial damage in the acute phases of DENV infection in patients with SD |
| Disciplinas: | Medicina |
| Palabras clave: | Inmunología, Dengue, Citocinas, Mediadores inflamatorios, Daño endotelial |
| Keyword: | Medicine, Immunology, Dengue, Cytokines, Inflammatory mediators, Endothelial damage |
| Texte intégral: | Texto completo (Ver PDF) |
