Inflammatory mediators in patients with Dengue infection: role in early endothelial damage



Título del documento: Inflammatory mediators in patients with Dengue infection: role in early endothelial damage
Revista: Avances en biomedicina
Base de datos: PERIÓDICA
Número de sistema: 000379323
ISSN: 2244-7881
Autors: 1
Institucions: 1Universidad de Los Andes, Facultad de Medicina, Mérida. Venezuela
Any:
Període: Oct
Volum: 2
Paginació: 48-48
País: Venezuela
Idioma: Inglés
Tipo de documento: Resúmenes
Enfoque: Experimental, aplicado
Resumen en inglés Several mechanisms have been proposed to explain the pathogenesis of dengue virus (DENV) infection. One of the most important finding is the production of pro-inflammatory cytokines as responsible of endothelial cells activation, plasma leakage and subsequently, disease severity. Methods: Our aim was to determined levels of inflammatory mediators (IL-8, TNF-α), soluble cell adhesion molecules (sICAM-1 and sVCAM-1) and soluble lymphocyte activation markers (sIL-2Rα, sTNF-RII/p75) during the course of DENV infection. Serum samples from fifty-two patients with confirmed DENV infection were collected during the acute (0-3 days after fever onset) and critical/recovery (4-7 days after onset) phases of the diseases. As controls, sera from non-febrile individuals were included. Patients were classified as dengue without warning signs (DwoWS), dengue with warning signs (DwWS) and severe dengue (SD). Results: Levels of sIL-8 and sTNF-α were significant higher in cases of DwWS during the critical phase of the disease. A significant increase of sICAM-1 and sVCAM-1 were detected during the critical phase of the disease compare with controls, however, the highest levels of sVCAM-1 were observed during the acute phase of SD. Finally, sIL2-R showed a significantly increased during the acute phases of SD, while sTNF-RII/p75 was elevated in DwWS during the critical stage of infection. Conclusion: sIL2-R and sVCAM-1 may be early markers of lymphocyte and endothelial damage in the acute phases of DENV infection in patients with SD
Disciplines Medicina
Paraules clau: Inmunología,
Dengue,
Citocinas,
Mediadores inflamatorios,
Daño endotelial
Keyword: Medicine,
Immunology,
Dengue,
Cytokines,
Inflammatory mediators,
Endothelial damage
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