| Revue: | ARBS. Annual review of biomedical sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000351973 |
| ISSN: | 1678-4618 |
| Autores: | Báez Saldaña, Armida1 Fetter Pruneda, Ingrid1 Fuentes Farías, Alma L2 Granados Rojas, Leticia3 Gutiérrez Ospina, Gabriel1 Martínez Méndez, Raquel1 Meléndez Herrera, Esperanza2 Mendoza Torreblanca, Julieta3 Sandoval Velasco, Marcela1 |
| Instituciones: | 1Universidad Nacional Autónoma de México, Instituto de Investigaciones Biomédicas, México, Distrito Federal. México 2Universidad Michoacana de San Nicolás de Hidalgo, Facultad de Biología, Morelia, Michoacán. México 3Instituto Nacional de Pediatría, Subdirección de Medicina Experimental, México, México, Distrito Federal. México |
| Año: | 2009 |
| Volumen: | 11 |
| Paginación: | 114-114T122 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | It has been long thought that the brain reorganizes itself in response to environmental needs. Sensory experiences coded in action potentials are the mean by which information on the surroundings is introduced into neuronal networks. The information approaching the brain in the form of electrochemical codes must then be translated in biochemical, epigenetic and genetic ones. Only until recently we have begun understanding the underpinning of such informational transformations and how this process is expressed as neuronal plastic responses. Central for our comprehension of this matter is the finding that signals transduction cascades can modify gene expression by remodeling the chromatin through epigenetic mechanisms. Hence, chromatin remodeling seems to be the process by which experiences are “imprinted” in the genome leading to differential gene expression and brain plasticity. In this review, we briefly comment on this possibility |
| Disciplinas: | Biología |
| Palabras clave: | Biología celular, Neurología, Plasticidad cerebral, Expresión génica, Epigénesis, Transducción de señales, Remodelación de cromatina |
| Keyword: | Biology, Cell biology, Neurology, Brain plasticity, Gene expression, Epigenesis, Signal transduction, Chromatin remodelling |
| Texte intégral: | Texto completo (Ver PDF) |
