Brain Plasticity, Signal Transduction and Epigenesis: a Missing Link Revealed



Título del documento: Brain Plasticity, Signal Transduction and Epigenesis: a Missing Link Revealed
Revista: ARBS. Annual review of biomedical sciences
Base de datos: PERIÓDICA
Número de sistema: 000351973
ISSN: 1678-4618
Autores: 1
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2
3
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3
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Instituciones: 1Universidad Nacional Autónoma de México, Instituto de Investigaciones Biomédicas, México, Distrito Federal. México
2Universidad Michoacana de San Nicolás de Hidalgo, Facultad de Biología, Morelia, Michoacán. México
3Instituto Nacional de Pediatría, Subdirección de Medicina Experimental, México, México, Distrito Federal. México
Año:
Volumen: 11
Paginación: 114-114T122
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés It has been long thought that the brain reorganizes itself in response to environmental needs. Sensory experiences coded in action potentials are the mean by which information on the surroundings is introduced into neuronal networks. The information approaching the brain in the form of electrochemical codes must then be translated in biochemical, epigenetic and genetic ones. Only until recently we have begun understanding the underpinning of such informational transformations and how this process is expressed as neuronal plastic responses. Central for our comprehension of this matter is the finding that signals transduction cascades can modify gene expression by remodeling the chromatin through epigenetic mechanisms. Hence, chromatin remodeling seems to be the process by which experiences are “imprinted” in the genome leading to differential gene expression and brain plasticity. In this review, we briefly comment on this possibility
Disciplinas: Biología
Palabras clave: Biología celular,
Neurología,
Plasticidad cerebral,
Expresión génica,
Epigénesis,
Transducción de señales,
Remodelación de cromatina
Keyword: Biology,
Cell biology,
Neurology,
Brain plasticity,
Gene expression,
Epigenesis,
Signal transduction,
Chromatin remodelling
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