Usefulness of acoustic radiation force impulse a nd fibrotest in liver fibrosis assessment after liver transplant
Título del documento: Usefulness of acoustic radiation force impulse a nd fibrotest in liver fibrosis assessment after liver transplant
Revue: Annals of hepatology
Base de datos: PERIÓDICA
Número de sistema: 000409078
ISSN: 1665-2681
Autores: 1
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Instituciones: 1University of Udine, Sezione Medica di Trapianto di Fegato, Udine, Friuli Venezia Giuli. Italia
Año:
Volumen: 15
Número: 2
Paginación: 200-206
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Aplicado, descriptivo
Resumen en inglés Acoustic radiation force impulse (ARFI) is a non-invasive tool used in the evaluation of liver fibrosis in HCV positive immune-competent patients. This study aimed to assess the accuracy of ARFI in discriminating liver transplanted patients with different graft fibrosis severity and to verify whether ARFI, eventually combined with non-invasive biochemical tests, could spare liver biopsies. This prospective study included 51 HCV positive liver transplanted patients who consecutively underwent to annual liver biopsy concomitantly with ARFI and blood chemistry tests measurements needed to calculate several non-invasive liver fibrosis tests. Results. Results. Results. Overall ARFI showed an AUC of 0.885 in discriminating between patients without or with significant fibrosis (Ishak score 0-2vs. 3-6). Using a cut-off of 1.365 m/s, ARFI possesses a negative predictive value of 100% in identifying patients without significant fibrosis. AUC for Fibrotest was 0.848 in discriminating patients with Ishak fibrosis score 0-2 vs. 3-6. The combined assessment of ARFI and Fibro-test did not improve the results obtained by ARFI alone. Conclusion. Conclusion. Conclusion. ARFI measurement in HCV positive liver transplanted patients can be considered an easy and accurate non-invasive tool in identify patients with a benign course of HCV recurrence
Disciplinas: Medicina
Palabras clave: Diagnóstico,
Gastroenterología,
Trasplante de hígado,
Métodos no invasivos,
Fibrosis hepática,
Cirrosis,
Virus de la hepatitis C,
Impulso de fuerza de radiación acústica
Keyword: Medicine,
Diagnosis,
Gastroenterology,
Liver transplantation,
Non-invasive methods,
Liver fibrosis,
Cirrhosis,
Acoustic radiation force impulse,
Hepatitis C virus
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