| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000409078 |
| ISSN: | 1665-2681 |
| Authors: | Bignulin, Sara1 Falleti, Edmondo1 Cmet, Sara1 Cappello, Dario1 Cussigh, Annarosa1 Toniutto, Pierluigi1 Lenisa, Ilaria1 Dissegna, Denis1 Pugliese, Fabio1 Vivarelli, Cinzia1 Fabris, Carlo1 |
| Institutions: | 1University of Udine, Sezione Medica di Trapianto di Fegato, Udine, Friuli Venezia Giuli. Italia |
| Year: | 2016 |
| Volumen: | 15 |
| Number: | 2 |
| Pages: | 200-206 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Aplicado, descriptivo |
| English abstract | Acoustic radiation force impulse (ARFI) is a non-invasive tool used in the evaluation of liver fibrosis in HCV positive immune-competent patients. This study aimed to assess the accuracy of ARFI in discriminating liver transplanted patients with different graft fibrosis severity and to verify whether ARFI, eventually combined with non-invasive biochemical tests, could spare liver biopsies. This prospective study included 51 HCV positive liver transplanted patients who consecutively underwent to annual liver biopsy concomitantly with ARFI and blood chemistry tests measurements needed to calculate several non-invasive liver fibrosis tests. Results. Results. Results. Overall ARFI showed an AUC of 0.885 in discriminating between patients without or with significant fibrosis (Ishak score 0-2vs. 3-6). Using a cut-off of 1.365 m/s, ARFI possesses a negative predictive value of 100% in identifying patients without significant fibrosis. AUC for Fibrotest was 0.848 in discriminating patients with Ishak fibrosis score 0-2 vs. 3-6. The combined assessment of ARFI and Fibro-test did not improve the results obtained by ARFI alone. Conclusion. Conclusion. Conclusion. ARFI measurement in HCV positive liver transplanted patients can be considered an easy and accurate non-invasive tool in identify patients with a benign course of HCV recurrence |
| Disciplines: | Medicina |
| Keyword: | Diagnóstico, Gastroenterología, Trasplante de hígado, Métodos no invasivos, Fibrosis hepática, Cirrosis, Virus de la hepatitis C, Impulso de fuerza de radiación acústica |
| Keyword: | Medicine, Diagnosis, Gastroenterology, Liver transplantation, Non-invasive methods, Liver fibrosis, Cirrhosis, Acoustic radiation force impulse, Hepatitis C virus |
| Full text: | Texto completo (Ver PDF) |
