Revue: | Anais da Academia Brasileira de Ciencias |
Base de datos: | PERIÓDICA |
Número de sistema: | 000408987 |
ISSN: | 0001-3765 |
Autores: | Kwon, Da Hye1 Jeong, Jin Woo2 Choi, Eun Ok2 Lee, Hye Won3 Lee, Ki Won4 Kim, Ki Young4 Kim, Sung Goo4 Hong, Su Hyun1 Kim, Gi-Young5 Park, Cheol6 Hwang, Hye-Jin7 Son, Chang-Gue8 Choi, Yung Hyun1 |
Instituciones: | 1Dongeui University, Department of Biochemistry, Busan. Corea del Sur 2Dongeui University, Anti-Aging Research Center, Busan. Corea del Sur 3Korea Institute of Oriental Medicine, Daejeon, Chungcheong del Sur. Corea del Sur 4Marine Bio-industry Development Center, Busan. Corea del Sur 5Jeju National University, Laboratory of Immunology, Jeju. Corea del Sur 6Dongeui University, Department of Molecular Biology, Busan. Corea del Sur 7Dongeui University, Department of Food and Nutrition, Busan. Corea del Sur 8Daejeon University, Liver and Immunology Research Center, Daejeon, Chungcheong del Sur. Corea del Sur |
Año: | 2017 |
Periodo: | May |
Volumen: | 89 |
Paginación: | 661-674 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Analítico, descriptivo |
Resumen en inglés | Mori folium, the leaf of Morus alba L. (Moraceae), has been traditionally used for various medicinal purposes from ancient times to the present. In this study, we examined the effects of water extract of Mori folium (WEMF) on the production of inflammatory mediators, such as nitric oxide (NO) and prostaglandin E 2 (PGE 2 ), and reactive oxygen species (ROS) in lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophages. Our data indicated that WEMF significantly suppressed the secretion of NO and PGE 2 in RAW 264.7 macrophages without any significant cytotoxicity. The protective effects were accompanied by a marked reduction in their regulatory gene expression at the transcription level. WEMF attenuated LPS- induced intracellular ROS production in RAW 264.7 macrophages. It inhibited the nuclear translocation of the nuclear factor-kappa B p65 subunit and the activation of mitogen-activated protein kinases in LPS- treated RAW 264.7 macrophages. Furthermore, WEMF reduced LPS-induced NO production and ROS accumulation in zebrafish. Although more efforts are needed to fully understand the critical role of WEMF in the inhibition of inflammation, the findings of the present study may provide insights into the approaches for Mori folium as a potential therapeutic agent for inflammatory and antioxidant disorders |
Disciplinas: | Química, Medicina |
Palabras clave: | Fitoquímica, Terapéutica y rehabilitación, Peces, Morus alba, Mori folium, Inflamación, Especies reactivas de oxígeno (ROS), Macrófagos, Pez cebra |
Keyword: | Chemistry, Medicine, Phytochemistry, Therapeutics and rehabilitation, Fish, Morus alba, Mori folium, Inflammation, Reactive oxygen species (ROS), Macrophages, Zebra fish |
Texte intégral: | Texto completo (Ver PDF) |