| Revue: | Anais da Academia Brasileira de Ciencias |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000436195 |
| ISSN: | 0001-3765 |
| Autores: | Bilgin, Asli O1 Mammadov, Renad1 Suleyman, Bahadir1 Unver, Edhem1 Ozcicek, Fatih1 Soyturk, Mehmet1 Cimen, Ferda K1 Kurt, Nezahat2 Suleyman, Halis1 |
| Instituciones: | 1Erzincan Binali Yildirim University, Faculty of Medicine, Erzincan. Turquía 2Ataturk University, Faculty of Medicine, Erzurum. Turquía |
| Año: | 2020 |
| Volumen: | 92 |
| Número: | 1 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Cytarabine is effectively used in the treatment of adult acute leukemia, but it has a dose-limiting side effect of fatal pulmonary oedema because it increases the vascular permeability of the alveolar capillaries. The aim of the present study was to conduct a radiological, biochemical and histopathological investigation of the effect of rutin on cytarabine-associated pulmonary oedema in rats. Rats were treated with a combination of rutin+cytarabine by administering oral rutin at a dose of 50 mg/kg; other rat groups were orally administered the same volume of physiological saline. One hour after administration of rutin or saline, the rutin+cytarabine and cytarabine groups received an intraperitoneal injection of cytarabine (200 mg/kg). This administration procedure was repeated once a day for 14 days. Radiologically, 50% of the animals given cytarabine alone showed lung oedema, but the rutin+cytarabine group showed no oedema. The inclusion of rutin decreased the amounts of cytarabine-associated malondialdehyde, tumour necrosis factor-α, and nuclear factor-κB in the lung tissue. Rutin also inhibited the reduction of total glutathione by nitric oxide. These findings suggest that rutin may be a beneficial adjunct that can minimise the development of cytarabine-associated pulmonary oedema |
| Disciplinas: | Medicina |
| Palabras clave: | Farmacología, Medicina experimental, Edema pulmonar, Estrés oxidativo, Rutina |
| Keyword: | Pharmacology, Experimental medicine, Pulmonary edema, Oxidative stress, Rutin |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
