Effect of Rutin on Cytarabine-Associated Pulmonary Oedema and Oxidative Stress in Rats



Título del documento: Effect of Rutin on Cytarabine-Associated Pulmonary Oedema and Oxidative Stress in Rats
Revista: Anais da Academia Brasileira de Ciencias
Base de datos: PERIÓDICA
Número de sistema: 000436195
ISSN: 0001-3765
Autores: 1
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Instituciones: 1Erzincan Binali Yildirim University, Faculty of Medicine, Erzincan. Turquía
2Ataturk University, Faculty of Medicine, Erzurum. Turquía
Año:
Volumen: 92
Número: 1
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Cytarabine is effectively used in the treatment of adult acute leukemia, but it has a dose-limiting side effect of fatal pulmonary oedema because it increases the vascular permeability of the alveolar capillaries. The aim of the present study was to conduct a radiological, biochemical and histopathological investigation of the effect of rutin on cytarabine-associated pulmonary oedema in rats. Rats were treated with a combination of rutin+cytarabine by administering oral rutin at a dose of 50 mg/kg; other rat groups were orally administered the same volume of physiological saline. One hour after administration of rutin or saline, the rutin+cytarabine and cytarabine groups received an intraperitoneal injection of cytarabine (200 mg/kg). This administration procedure was repeated once a day for 14 days. Radiologically, 50% of the animals given cytarabine alone showed lung oedema, but the rutin+cytarabine group showed no oedema. The inclusion of rutin decreased the amounts of cytarabine-associated malondialdehyde, tumour necrosis factor-α, and nuclear factor-κB in the lung tissue. Rutin also inhibited the reduction of total glutathione by nitric oxide. These findings suggest that rutin may be a beneficial adjunct that can minimise the development of cytarabine-associated pulmonary oedema
Disciplinas: Medicina
Palabras clave: Farmacología,
Medicina experimental,
Edema pulmonar,
Estrés oxidativo,
Rutina
Keyword: Pharmacology,
Experimental medicine,
Pulmonary edema,
Oxidative stress,
Rutin
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