Revue: | Anais brasileiros de dermatologia |
Base de datos: | PERIÓDICA |
Número de sistema: | 000393793 |
ISSN: | 0365-0596 |
Autores: | Cabete, Joana1 Rafael, Margarida2 Cravo, Mariana2 Moura, Cecilia2 Sachse, Fernanda2 Pecegueiro, Manuela2 |
Instituciones: | 1Centro Hospitalar de Lisboa Central, Hospital de Santo Antonio dos Capuchos, Lisboa. Portugal 2Instituto Portugues de Oncologia de Lisboa Francisco Gentil, Lisboa. Portugal |
Año: | 2015 |
Periodo: | Nov-Dic |
Volumen: | 90 |
Número: | 6 |
Paginación: | 846-850 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Estadística o encuesta |
Enfoque: | Caso clínico |
Resumen en inglés | Most available studies on the efficacy of topical photodynamic therapy focus on short-to medium-term results. Long-term data are scarce. OBJECTIVE: To evaluate the long-term efficacy of photodynamic therapy with topical methylaminolevulinate to treat Bowen's disease and basal cell carcinoma in the clinical practice setting of a dermato-oncology department. METHODS: The study included patients diagnosed with Bowen's disease or basal cell carcinoma, and who received photodynamic therapy from 2004 to 2008. Treatment protocol and clinical follow-up were standardized. The primary endpoint was clinically observed recurrence in a previous photodynamic therapy-treated area. Descriptive and survival analyses were performed. RESULTS: A total of 31 Bowen's disease lesions and 44 superficial basal cell carcinoma were treated, with a median follow-up of 43.5 months. Recurrence was observed in 14 Bowen's disease lesions (53.8%) and in 11 superficial basal cell carcinoma (33.3%). Significantly higher estimates for recurrence rates were found in patients with Bowen's disease (p=0.0036) or those aged under 58 years (p=0.039). The risk of recurrence was higher in patients with Bowen's disease than in those with superficial basal cell carcinoma and younger patients. CONCLUSIONS: Recurrence should be considered when choosing to treat non-melanoma skin cancer with photodynamic therapy. Younger age and Bowen's disease were independent predictors for long-term recurrence, suggesting the need to establish an extended period of follow-up for this subset of patients |
Disciplinas: | Medicina |
Palabras clave: | Dermatología, Oncología, Enfermedad de Bowen, Carcinoma basocelular, Piel, Neoplasias, Terapia fotodinámica, Recurrencia |
Keyword: | Medicine, Dermatology, Oncology, Bowen disease, Carcinoma, Basal cell carcinoma, Skin, Neoplasms, Photodynamic therapy, Recurrence |
Texte intégral: | Texto completo (Ver HTML) |