Long-term recurrence of nonmelanoma skin cancer after topical methylaminolevulinate photodynamic therapy in a dermato-oncology department
Título del documento: Long-term recurrence of nonmelanoma skin cancer after topical methylaminolevulinate photodynamic therapy in a dermato-oncology department
Revista: Anais brasileiros de dermatologia
Base de datos: PERIÓDICA
Número de sistema: 000393793
ISSN: 0365-0596
Autors: 1
2
2
2
2
2
Institucions: 1Centro Hospitalar de Lisboa Central, Hospital de Santo Antonio dos Capuchos, Lisboa. Portugal
2Instituto Portugues de Oncologia de Lisboa Francisco Gentil, Lisboa. Portugal
Any:
Període: Nov-Dic
Volum: 90
Número: 6
Paginació: 846-850
País: Brasil
Idioma: Inglés
Tipo de documento: Estadística o encuesta
Enfoque: Caso clínico
Resumen en inglés Most available studies on the efficacy of topical photodynamic therapy focus on short-to medium-term results. Long-term data are scarce. OBJECTIVE: To evaluate the long-term efficacy of photodynamic therapy with topical methylaminolevulinate to treat Bowen's disease and basal cell carcinoma in the clinical practice setting of a dermato-oncology department. METHODS: The study included patients diagnosed with Bowen's disease or basal cell carcinoma, and who received photodynamic therapy from 2004 to 2008. Treatment protocol and clinical follow-up were standardized. The primary endpoint was clinically observed recurrence in a previous photodynamic therapy-treated area. Descriptive and survival analyses were performed. RESULTS: A total of 31 Bowen's disease lesions and 44 superficial basal cell carcinoma were treated, with a median follow-up of 43.5 months. Recurrence was observed in 14 Bowen's disease lesions (53.8%) and in 11 superficial basal cell carcinoma (33.3%). Significantly higher estimates for recurrence rates were found in patients with Bowen's disease (p=0.0036) or those aged under 58 years (p=0.039). The risk of recurrence was higher in patients with Bowen's disease than in those with superficial basal cell carcinoma and younger patients. CONCLUSIONS: Recurrence should be considered when choosing to treat non-melanoma skin cancer with photodynamic therapy. Younger age and Bowen's disease were independent predictors for long-term recurrence, suggesting the need to establish an extended period of follow-up for this subset of patients
Disciplines Medicina
Paraules clau: Dermatología,
Oncología,
Enfermedad de Bowen,
Carcinoma basocelular,
Piel,
Neoplasias,
Terapia fotodinámica,
Recurrencia
Keyword: Medicine,
Dermatology,
Oncology,
Bowen disease,
Carcinoma,
Basal cell carcinoma,
Skin,
Neoplasms,
Photodynamic therapy,
Recurrence
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