Behavioral model of a basic trabecular-bone multi-cellular unit using cellular automaton



Document title: Behavioral model of a basic trabecular-bone multi-cellular unit using cellular automaton
Journal: Visión electrónica
Database: PERIÓDICA
System number: 000461400
ISSN: 1909-9746
Authors: 1
Institutions: 1Universidad Distrital Francisco José de Caldas, Bogotá. Colombia
Year:
Season: Ene-Jun
Volumen: 8
Number: 1
Pages: 6-18
Country: Colombia
Language: Inglés
Document type: Artículo
Approach: Experimental aplicado
English abstract bone remodeling is the biological process through which old bone tis-sue is transformed into new bone through the action of a basic unit of bone remodeling (bmu). This paper presents a computational model to determine the variation of cell population caused by the presence of micro-fractures within the bmu during the remodeling process, also determines the spatial evolution at particular points of the trabecular bone surface. The remodeling process presented is governed by a two-dimensional cellular automaton that evolves according to a set of rules and states, based on biological processes that occur in bone remodeling. The simulation of the remodeling process, programmed in maTLab® performed in time intervals of 0.3 seconds, in the model showed a ratio of 20 osteoclasts to 190 osteoblasts. On the other hand, an approximate resorption time of 34 days and 150 days for formation was obtained. bone mass showed a maximum percentage loss of 19%
Disciplines: Ciencias de la computación,
Medicina
Keyword: Conteo celular,
Estructura trabecular,
Modelos computacionales,
Remodelación ósea
Keyword: Bone remodelling,
Cell count,
Computational models,
Trabecular structure
Full text: https://revistas.udistrital.edu.co/index.php/visele/article/view/7855/9586