Anesthetic evaluation of a novel phospholipid-free 1% propofol microemulsion formulation in dogs
Document title: Anesthetic evaluation of a novel phospholipid-free 1% propofol microemulsion formulation in dogs
Journal: Veterinaria México OA
Database: PERIÓDICA
System number: 000439057
ISSN: 2007-5472
Authors: 1
2
1
1
3
1
Institutions: 1Universidad Nacional Autónoma de México, Facultad de Medicina Veterinaria, Ciudad de México. México
2Universidad Autónoma de Yucatán, Facultad de Medicina Veterinaria y Zootecnia, Mérida, Yucatán. México
3Universidad Nacional Autónoma de México, Facultad de Química, Ciudad de México. México
Year:
Season: Jul-Sep
Volumen: 6
Number: 3
Country: México
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract A novel four-week stable experimental formulation of propofol lacking phospholipids (PMICRO) was assessed as an anesthetic agent in dogs and compared to the customary preparation of propofol that contains phospholipids (PMACRO). Forty healthy mixed-breed dogs were included in this study and randomly assigned (blocking by sex and age), to receive 5 mg/kg of one of these two pharmaceutical propofol preparations, by intravenous injection. Basal and post anesthetic blood biochemical parameters were measured. Also, cardiovascular and respiratory rates were recorded. Onset, duration and recovery from anesthesia, were documented as well. Overall, IV administration of PMICRO induces a short duration anesthesia with rapid recovery in a similar manner to anesthesia achieved with the customary propofol preparation (PMACRO). Because PMICRO lacks phospholipids, it may allow a longer storage time, decreasing the likeliness of accidental administration of contaminated propofol
Disciplines: Medicina veterinaria y zootecnia
Keyword: Medicina veterinaria,
Propofol,
Fosfolípidos,
Anestesia,
Perros,
Microemulsiones
Keyword: Veterinary medicine,
Anesthesia,
Dogs,
Microemulsions,
Phospholipids,
Propofol
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