Use of fibrin glue derived from snake venom in testicular biopsy of rams



Document title: Use of fibrin glue derived from snake venom in testicular biopsy of rams
Journal: The journal of venomous animals and toxins
Database: PERIÓDICA
System number: 000298635
ISSN: 0104-7930
Authors: 1

2
3


Institutions: 1Universidade Estadual Paulista "Julio de Mesquita Filho", Faculdade de Medicina Veterinaria e Zootecnia, Botucatu, Sao Paulo. Brasil
2Universidade Estadual Paulista "Julio de Mesquita Filho", Faculdade de Medicina de Botucatu, Botucatu, Sao Paulo. Brasil
3Universidade Estadual Paulista "Julio de Mesquita Filho", Faculdade de Ciencias Farmaceuticas de Araraquara, Araraquara, Sao Paulo. Brasil
Year:
Volumen: 4
Number: 1
Pages: 23-35
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Sequelae due to testicular biopsy such as hemorrhage, adhesion and fibrosis may be limiting factors to the use of this surgical procedure. Fibrin glue (FG) derived from snake venom was used to minimize these sequelae, as well as to evaluate its healing property in tunica vaginalis and scrotal skin of rams. Applicability of fibrin glue derived from snake venom was tested in different tissues of other animals such as in sciatic nerve and colon of rats and skin of rabbits. In the present study, 30 healthy adult rams were used. They were divided into 3 groups of 10 animals each as follows: G1: fibrin glue group (application of fibrin glue on puncture sites and skin incisions after bilateral testicular biopsy with a Tru-Cut needle); G2: swab/nylon group (hemostasis by compression with a swab on puncture sites and skin suturing with nylon after biopsy) and G3: control group (the animals were not subjected either to biopsy or to surgery). On the 20<IMG SRC="Image485.gif" WIDTH=10 HEIGHT=17> day after biopsy, the presence of adhesion strands between the sites of skin incision and testicle was evaluated by palpation. Adhesion strands were found in three testicles (15%) in G1 and in two testicles (10%) in G2. One hundred days after biopsy, orchiectomy was carried out and the material collected was assessed for subcutaneous (SC) and/or tunica vaginalis adhesions. G3 did not present any abnormality. Groups G1 and G2 presented four testicles each (20%) with adhesion between the tunics at biopsy site. On the other hand, subcutane
Disciplines: Medicina veterinaria y zootecnia
Keyword: Medicina veterinaria,
Ovinos y caprinos,
Testículos,
Biopsia,
Carneros,
Adhesivos tisulares,
Fibrina,
Veneno de víbora
Keyword: Veterinary medicine and animal husbandry,
Sheep and goats,
Veterinary medicine,
Testicles,
Biopsy,
Rams,
Tissue adhesives,
Fibrin,
Snake venom
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