| Journal: | The journal of venomous animals and toxins |
| Database: | PERIÓDICA |
| System number: | 000298648 |
| ISSN: | 0104-7930 |
| Authors: | Murthy, K. Radha Krishna1 Zare, M. Abbas Haghnazari, L |
| Institutions: | 1Seth G.S. Medical College, Department of Physiology, Bombay, Maharashtra. India |
| Year: | 1999 |
| Volumen: | 5 |
| Number: | 2 |
| Pages: | 154-171 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental |
| English abstract | Acute myocardiopathy in experimental dogs and rabbits was induced by subcutaneous (SQ) injection of 3.5 mg/kg of scorpion venom from Mesobuthus tamulus concanesis, Pocock. An increase in circulating lactic dehydrogenase (LDH), serum glutamic oxalacetic transaminase (SGOT), creatine kinase-MB isoenzyme (CK-MB), serum glutamine pyrovate transaminase (SGPT) and alpha hydroxy butyrate dehydrogenase (HBDH) enzyme levels was observed in dogs 60 min after venom injection, and a further rise was observed 120 min after venom injection. The administration of the species-specific scorpion antivenom (SAV) at different time intervals after venom injection resulted in reversal of electrocardiographic changes and a reduction in cardiac enzyme levels. The administration of SAV to scorpion envenomed alloxan-pretreated animals did not cause clinical or biochemical improvement. On the other hand, administering insulin to envenomed only animals or envenomed alloxan-pretreated animals resulted in a biochemical and clinical improvement, as well as in a reduction of the cardiac enzyme levels. Insulin administration in scorpion envenoming syndrome is essentially a metabolic support to control the adverse effects triggered by catecholamines and other counter-regulatory hormones |
| Disciplines: | Medicina |
| Keyword: | Toxicología, Cardiología, Envenenamiento, Veneno de alacrán, Electrocardiografía, Glutamin oxaloacetato transaminasa, Glutamin piruvato transaminasa, Lactato deshidrogenasa, Creatina quinasa, Alfa hidroxi butirato deshidrogenasa, Mesobuthus tamulus concanesis |
| Keyword: | Medicine, Toxicology, Cardiology, Envenomation, Scorpion venom, Electrocardiography, Glutamine oxalacetate transaminase, Glutamine pyruvate transaminase, Lactate dehydrogenase, Creatine kinase, Alpha hydroxy butyrate dehydrogenase, Mesobuthus tamulus concanesis |
| Full text: | Texto completo (Ver HTML) |
