| Journal: | The journal of venomous animals and toxins |
| Database: | PERIÓDICA |
| System number: | 000298667 |
| ISSN: | 0104-7930 |
| Authors: | Radha Krishna Murthy, K1 Haghnazari, L |
| Institutions: | 1Seth G.S. Medical College, Department of Physiology, Parel, Mumbai. India |
| Year: | 1999 |
| Volumen: | 5 |
| Number: | 1 |
| Pages: | 47-55 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental |
| English abstract | Severe envenoming was induced in two groups of experimental dogs after subcutaneous (SQ) injection of venom of the scorpion (Mesobuthus tamulus concanesis, Pocock) (3.0 and 3.5 mg/kg body weight). The circulating levels of blood sugar, insulin, glucagon, and cortisol were assayed at 0, and 30, 60, 90 and 120 min after venom injection. There was an increase in the circulating levels of blood sugar, insulin, glucagon, and cortisol following envenoming. Scorpion envenoming causes an autonomic storm resulting in a massive release of catecholamines, angiotensin II, glucagon, and cortisol accompanied by changes in insulin secretion. The rise in the counter-regulatory hormones (glucagon, cortisol, and catecholamines) oppose the anabolic actions of insulin resulting in a variety of clinical manifestations. These changes may lead to a syndrome of fuel-energy deficits and to an inability of the vital organs to utilise the existing metabolic substrates, ultimately resulting in multisystem organ failure (MSOF) and death |
| Disciplines: | Medicina |
| Keyword: | Medicina experimental, Toxicología, Veneno de alacrán, Insulina, Glucagón, Cortisol, Mesobuthus tamulus concanesis |
| Keyword: | Medicine, Experimental medicine, Toxicology, Scorpion venom, Insulin, Glucagon, Cortisol, Mesobuthus tamulus concanesis |
| Full text: | Texto completo (Ver HTML) |
