Antitumor effect of snake venoms
Document title: Antitumor effect of snake venoms
Journal: The journal of venomous animals and toxins
Database: PERIÓDICA
System number: 000298551
ISSN: 0104-7930
Authors: 1
2
Institutions: 1Universidade Estadual Paulista "Julio de Mesquita Filho", Centro de Estudos de Venenos e Animais Peconhentos, Sao Paulo. Brasil
2Universidade Estadual Paulista "Julio de Mesquita Filho", Faculdade de Medicina de Botucatu, Botucatu, Sao Paulo. Brasil
Year:
Volumen: 2
Number: 2
Pages: 79-90
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract The search for biological antitumor agents has been pursued for over half a century. Snake venom has been shown to possess a wide spectrum of biological activities. The objectives of the present review are to evaluate the existing controversies on this subject published in a number of papers and to propose probable explanations for the phenomena observed. We reported our results obtained in a study, in which we evaluated the action of the venoms of Crotalus durissus terrificus and Bothrops jararaca on Ehrlich ascites tumor cells. We noticed an important antitumor effect, mainly with Bothrops jararaca venom, as well as an increase in the functional activity of macrophages. We also observed an increase in the number of mononuclear and polymorphonuclear cells with Bothrops jararaca venom. Considering these findings, we postulate that both Bothrops jararaca and Crotalus durissus terrificus venoms can act directly on tumor cells. In addition, we propose an indirect mechanism, based on the stimulation of the inflammatory response, to inhibit tumor growth and to promote its rejection
Disciplines: Medicina
Keyword: Medicina experimental,
Oncología,
Cáncer,
Inflamación,
Veneno de víbora,
Crotalus durissus terrificus,
Bothrops jararaca
Keyword: Medicine,
Experimental medicine,
Oncology,
Cancer,
Inflammation,
Snake venom,
Crotalus durissus terrificus,
Bothrops jararaca
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