| Journal: | The journal of venomous animals and toxins including tropical diseases |
| Database: | PERIÓDICA |
| System number: | 000298775 |
| ISSN: | 1678-9199 |
| Authors: | Lipps, B.V1 |
| Institutions: | 1Ophidia Products Inc., Houston, Texas. Estados Unidos de América |
| Year: | 2003 |
| Volumen: | 9 |
| Number: | 2 |
| Pages: | 239-254 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Aplicado, descriptivo |
| English abstract | Adenosine deaminase (ADA), histamine, and IgE are endogenously present in animals. Research from this laboratory reported decreased levels of these substances in organs of mice as a consequence of sub-lethal injection of Naja kaouthia venom. This research reports that decreased ADA, histamine, and IgE levels were prevented by specific treatment and prolonged recovery periods. Adult Balb/c mice injected IM with sub-lethal venom dose were divided into five groups. Group 1 were injected with PBS; Group 2 with anti-cobra venom; and Group 3 with lethal toxin neutralizing factor (LTNF). Groups 4 and 5 were treated with IM or oral synthetic LT-10. After 24 hours, mice were sacrificed and organ homogenates were assayed for ADA, histamine, and IgE. Group 1 showed substantial reduction in levels of these substances. It was revealed that decreased levels were prevented by treatment with anti-cobra venom, LTNF, and LT-10. In a second series of experiments, venom-injected mice were sacrificed after 3, 7, and 10 days and organs assayed for ADA, histamine, and IgE levels. The recovery period to homeostasis for ADA, histamine, and IgE was 7 to 10 days |
| Disciplines: | Medicina |
| Keyword: | Medicina experimental, Toxicología, Veneno de víbora, Ratones, Antivenenos, Factor neutralizante de toxinas letales, Homeostasis, Naja kaouthia, Elapidae |
| Keyword: | Medicine, Experimental medicine, Toxicology, Snake venom, Mice, Antivenoms, Lethal toxin neutralizing factor, Homeostasis, Naja kaouthia, Elapidae |
| Full text: | Texto completo (Ver HTML) |
