| Journal: | The journal of venomous animals and toxins including tropical diseases |
| Database: | PERIÓDICA |
| System number: | 000298967 |
| ISSN: | 1678-9199 |
| Authors: | Gadag, J.R1 Mirajkar, K.K1 More, S |
| Institutions: | 1Karnatak University, Department of Biochemistry, Dharwad, Karnataka. India |
| Year: | 2006 |
| Volumen: | 12 |
| Number: | 1 |
| Pages: | 78-90 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental |
| English abstract | The neurotoxin purified from the venom of Bungarus caeruleus causes a neuromuscular blockade on acetylcholine-induced muscle twitch response in isolated frog rectus abdominis muscle preparation. Neuromuscular blockade produced by d-tubocurarine on acetylcholine-induced muscle twitch response in an isolated frog rectus abdominis muscle preparation was reversed to normal muscle twitch response in presence of neostigmine. Whereas the purified neurotoxin produced an irreversible neuromuscular blockade in presence of the same strength of neostigmine. As it is already known, botulinum toxin, which also brings about neuromuscular blockade, is effectively used as a drug in the treatment of painful movement disorders. Since the purified toxin also causes paralysis of the muscle, we propose its possible efficacy in the treatment of neuromuscular disorders |
| Disciplines: | Biología |
| Keyword: | Fisiología animal, Bioquímica, Veneno de víbora, Neurotoxinas, Bloqueo neuromuscular, Bungarus caeruleus, Elapidae |
| Keyword: | Biology, Animal physiology, Biochemistry, Snake venom, Neurotoxins, Neuromuscular blockade, Bungarus caeruleus, Elapidae |
| Full text: | Texto completo (Ver HTML) |
