| Journal: | The journal of venomous animals and toxins including tropical diseases |
| Database: | PERIÓDICA |
| System number: | 000298874 |
| ISSN: | 1678-9199 |
| Authors: | Yonamine, C.M1 Costa, H Silva, J.A.A Muramoto, E Rogero, J.R Troncone, L.R.P2 Camillo, M.A.P |
| Institutions: | 1Comissao Nacional de Energia Nuclear, Instituto de Pesquisas Energeticas e Nucleares, Sao Paulo. Brasil 2Instituto Butantan, Laboratorio de Farmacología, Sao Paulo. Brasil |
| Year: | 2005 |
| Season: | Mar |
| Volumen: | 11 |
| Number: | 1 |
| Pages: | 39-50 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The use of radiotracers allows the understanding of the bioavailability process, biodistribution, and kinetics of any molecule labelled with an isotope, which does not alter the molecule's biological properties. In this work, technetium-99m and iodine-125 were chosen as radiotracers for biodistribution studies in mice using bee (Apis mellifera) venom and a toxin (PnTX2-6) from the Brazilian "armed" spider (Phoneutria nigriventer) venom. Incorporated radioactivity was measured in the blood, brain, heart, lung, liver, kidney, adrenal gland, spleen, stomach, testicle, intestine, muscle, and thyroid gland. Results provided the blood kinetic parameter, and different organs distribution rates |
| Disciplines: | Medicina |
| Keyword: | Medicina experimental, Toxicología, Toxinas, Veneno, Biodistribución, Radiotrazadores, Phoneutria nigriventer, Apis mellifera |
| Keyword: | Medicine, Experimental medicine, Toxicology, Toxins, Venom, Biodistribution, Radiotracers, Phoneutria nigriventer, Apis mellifera |
| Full text: | Texto completo (Ver HTML) |
