| Journal: | The journal of venomous animals and toxins including tropical diseases |
| Database: | PERIÓDICA |
| System number: | 000298980 |
| ISSN: | 1678-9199 |
| Authors: | Chudzinski-Tavassi, A.M1 Carrijo-Carvalho, L.C |
| Institutions: | 1Instituto Butantan, Laboratorio de Bioquimica e Biofisica, Sao Paulo. Brasil |
| Year: | 2006 |
| Season: | Abr |
| Volumen: | 12 |
| Number: | 2 |
| Pages: | 159-171 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Lonomia obliqua caterpillar is frequently seen in accidents with humans especially in the south of Brazil. Patients develop a hemorrhagic syndrome that can be treated with specific antilonomic serum. A consumptive coagulopathy was found to be the main cause of bleeding complications observed in patients after contact with L. obliqua. Studies revealed that L. obliqua caterpillar bristle extract (LOCBE) displays a procoagulant activity that leads to intravascular thrombin formation, resulting in a special form of disseminated intravascular coagulation (DIC). Fibrinolysis seems to be secondary to the fibrin production, since no direct fibrinolytic activity was found in LOCBE. Two procoagulant toxins, a factor X activator (Losac) and a prothrombin activator (Lopap), were isolated from LOCBE and characterized. Infusion of Lopap into experimental animals triggered a condition similar to that observed in human envenomation |
| Disciplines: | Medicina |
| Keyword: | Hematología, Toxicología, Insectos, Orugas, Cerdas, Envenenamiento, Síndrome hemorrágico, Coagulación intravascular diseminada, Lonomia obliqua, Lepidoptera |
| Keyword: | Medicine, Hematology, Toxicology, Insects, Caterpillars, Bristles, Envenomation, Hemorrhagic syndrome, Disseminated intravascular coagulation, Lonomia obliqua, Lepidoptera |
| Full text: | Texto completo (Ver HTML) |
