| Journal: | The journal of venomous animals and toxins including tropical diseases |
| Database: | PERIÓDICA |
| System number: | 000298792 |
| ISSN: | 1678-9199 |
| Authors: | Furtado, M.F.D1 Santos, M.C2 Kamiguti, A.S3 |
| Institutions: | 1Instituto Butantan, Laboratorio de Herpetologia, Sao Paulo. Brasil 2Universidade do Amazonas, Manaus, Amazonas. Brasil 3University of Liverpool, Department of Haematology, Liverpool, Lancashire. Reino Unido |
| Year: | 2003 |
| Volumen: | 9 |
| Number: | 2 |
| Pages: | 186-201 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental |
| English abstract | An in vitro and in vivo comparative study was performed on the effects of Crotalus durissus terrificus venoms from a mother and its 15 newborns. The venoms were tested for protein content, lethality, proteolytic, myotoxic, hemorrhagic, and phospholipase A2 activity. The minimum coagulant dose in plasma and human fibrinogen, protrhombin, and Factor II activations were analyzed. The venoms were also analyzed by polyacrylamide gel electrophoresis (PAGE). This showed that despite similar total protein content, the biological effects of the venoms were different. Venom from young snakes exhibited higher enzymatic and coagulant activities and higher myotoxicity compared to the mother’s. In addition, the PLA2 content paralleled myotoxicity. However, no difference could be detected in their toxicity (LD50 0.08 mg/Kg). High incidence of blood coagulation disorders and elevated circulating myoglobin may characterize systemic envenoming by young C. d. terrificus |
| Disciplines: | Biología |
| Keyword: | Reptiles, Toxicología, Veneno de víbora, Víbora de cascabel, Actividad biológica, Crotalus durissus terrificus, Viperidae |
| Keyword: | Biology, Reptiles, Toxicology, Snake venom, Rattlesnake, Biological activity, Crotalus durissus terrificus, Viperidae |
| Full text: | Texto completo (Ver HTML) |
