| Revista: | The brazilian journal of infectious diseases |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000290976 |
| ISSN: | 1413-8670 |
| Autores: | Tahan, Tony Tannous1 Bruck, Isac Burger, Marion Cruz, Cristina Rodrigues da |
| Instituciones: | 1Universidade Federal do Parana, Hospital Clinico, Curitiba, Parana. Brasil |
| Año: | 2006 |
| Periodo: | Oct |
| Volumen: | 10 |
| Número: | 5 |
| Paginación: | 322-326 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico |
| Resumen en inglés | This study evaluated the degree of neurological compromise in HIV-infected children accompanied by the outpatient clinic of infectious diseases and pediatric neurology of the Clinical Hospital of the Federal University of Paraná (UFPR) starting in 1995. Long-term progressive prospective and cross sectional study of 88 children infected by HIV and 84 seroreverter children, using data from general neurological examinations, neuroimaging procedures (brain CT scan) and neurodevelopmental tests (CAT/CLAMS and DENVER I and II). Neurological and neurodevelopmental alterations were found in 82% of the HIV-infected patients and in 36% of the HIV-seroreverter group (P <0.01). In the CAT/CLAMS test, the development quotient (DQ) of the HIV-infected group was significantly lower than that of the HIV-seroreverter group. CAT/CLAMS scores lower than 70 (mental deficiency) were found in 31% of the HIV-infected patients during the first year of life and in only 1% of the patients of the HIV-seroreverter group, demonstrating the validity of this screening test for precocious detection of alterations in the neurodevelopment of infected patients. The same occurred with the Denver I and II tests, as the HIV-infected group failed more frequently than the HIV-seroreverter group. Nine HIV-infected children presented altered brain CT scans; calcification of basal ganglia was the main finding (five cases). Encephalopathy due to HIV causes early arrest of neurodevelopment, which can be detected with screening tests during the first year of life |
| Disciplinas: | Medicina |
| Palabras clave: | Neurología, Pediatría, Inmunología, Niños, VIH, Evaluación neurológica, Encefalopatía |
| Keyword: | Medicine, Neurology, Pediatrics, Children, HIV, Neurological evaluation, Encephalopathy, Immunology |
| Texto completo: | Texto completo (Ver HTML) |
