| Journal: | The brazilian journal of infectious diseases |
| Database: | PERIÓDICA |
| System number: | 000290742 |
| ISSN: | 1413-8670 |
| Authors: | Darabi, Haideh1 Abolhassani, Mohsen Kariminia, Amina Alimohammadian, Mohammad H |
| Institutions: | 1Institut Pasteur, Departement d'Immunologie, Teherán. Irán |
| Year: | 2002 |
| Season: | Oct |
| Volumen: | 6 |
| Number: | 5 |
| Pages: | 258-262 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Caso clínico, analítico |
| English abstract | ABSTRACT The expansion of gd T cells in patients with active cutaneous leishmaniasis, with or without glucantime therapy, was investigated. Twenty patients with local cutaneous leishmaniasis including glucantime-treated (n=10) and untreated (n=10) patients were selected. The controls were healthy individuals (n=10) living in endemic areas. Whole blood was obtained and the T cell subpopulations were analyzed by flow cytometry. Significantly more gd CD3+ T cells were observed in untreated patients (15.9% ± 5.9), when compared with glucantime-treated patients (4.6% ± 1.4) and controls (5.3% ± 2.3). On the other hand, when the percentages of ab CD3+ T-cells were analyzed different results were obtained. A significant increase in ab T cells was seen in glucantime-treated patients (62.4% ± 7.6), when compared to the untreated patients (55.7% ± 5.5) and controls (55.1% ± 9.6). The percentage of total CD3+ T cells was statistically greater in both glucantime-treated (68.8% ± 7.4) and untreated patients (73.4% ± 5.9) when compared to the controls (61% ± 10.3). These results are consistent with previous results on the expansion of gd T cells during the course of cutaneous leishmaniasis. They also indicate that glucantime therapy can reverse the expansion of gd T cells and as a result increase the percentages of ab CD3+ T cells |
| Disciplines: | Biología, Medicina |
| Keyword: | Inmunología, Parasitología, Hematología, Leishmaniasis cutánea, Células T gamma delta, Terapia glucatime |
| Keyword: | Biology, Medicine, Immunology, Parasitology, Hematology, Cutaneous leishmaniasis, Gamma-delta T cells, Glucantime therapy |
| Full text: | Texto completo (Ver HTML) |
