| Journal: | The brazilian journal of infectious diseases |
| Database: | PERIÓDICA |
| System number: | 000290674 |
| ISSN: | 1413-8670 |
| Authors: | Colombo, Arnaldo Lopes1 Queiroz-Telles, Flavio Silva, Nanci2 Carvalho, Miriam M3 Alcantara, Ana Paula Matta, Daniel da4 Barberino, Maria G Bartczak, Sergio5 |
| Institutions: | 1Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Sao Paulo. Brasil 2Hospital Alianca, Salvador, Bahia. Brasil 3Universidade Federal do Parana, Hospital das Clinicas, Curitiba, Parana. Brasil 4Universidade Federal de Sao Paulo, Laboratorio de Micologia, Sao Paulo. Brasil 5Janssen-Cilag Farmaceutica do Brasil, Sao Paulo. Brasil |
| Year: | 2001 |
| Season: | Abr |
| Volumen: | 5 |
| Number: | 2 |
| Pages: | 60-66 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Caso clínico |
| English abstract | This study was a non-comparative multicenter clinical trial to evaluate the efficacy and tolerability of itraconazole oral solution 200 mg/day (100 mg twice a day in the fasting state) for the treatment of oropharyngeal candidiasis in AIDS patients. We included 50 patients who were treated and followed for up to 3 weeks after ending therapy in the analysis. Mycological cures at the end of therapy occurred in 20/50 patients (40%), but colonization by Candida sp. was recorded in 42/50 (84%) by the end of follow-up. A high rate of clinical response was observed in 46/50 (92%), and the response was sustained for up to 21 days after stopping therapy in 24/46 patients (52%). Clinical relapses were documented among 22 patients, but all causative fungal organisms associated with a relapse were susceptible to itraconazole. There were many patients with persistence or recurrence of Candida, but without mucositis. Relapse of Candida mucositis was significantly related to low levels of CD4 lymphocytes exhibited by symptomatic patients. The drug was well tolerated by all but 1 patient. We conclude that itraconazole oral solution (100 mg bid for 7-14 days) is a well tolerated and effective treatment for suppressing the symptoms of oropharyngeal candidiasis in AIDS patients. Patients with severe immunosuppression may relapse and require frequent cycles of treatment or longterm suppressive therapy |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Terapéutica y rehabilitación, Inmunología, SIDA, Candidiasis, Itraconazol |
| Keyword: | Medicine, Pharmacology, Therapeutics and rehabilitation, AIDS, Candidiasis, Itraconazole, Immunology |
| Full text: | Texto completo (Ver HTML) |
