| Journal: | The brazilian journal of infectious diseases |
| Database: | PERIÓDICA |
| System number: | 000291050 |
| ISSN: | 1413-8670 |
| Authors: | Andrade, Ana Cristina O1 Cotter, Bruno R2 |
| Institutions: | 1Universidade Federal da Bahia, Faculdade de Medicina da Bahia, Salvador, Bahia. Brasil 2University of California, San Diego, California. Estados Unidos de América |
| Year: | 2006 |
| Season: | Abr |
| Volumen: | 10 |
| Number: | 2 |
| Pages: | 139-145 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental |
| English abstract | The HIV epidemic has dramatically changed the paradigm for the development of drug therapy in the last 15 years. The goal is now not only to provide an effective reduction of plasma viremia , but also to reconstitute the immune deficiency due to the progression of the disease. Significant problems with the metabolism of sugars and lipids lead to the appearance of well-documented disorders such as insulin resistance, abnormalities in lipid metabolism and lipodystrophy in those patients on prolonged therapy with antiretrovirals. The question of whether or not HAART-associated lipid disorders contribute to the premature development of coronary artery disease is of major importance for the HIV community. Endothelial injury is associated with disease-related biochemical abnormalities that are implicated in HIV pathogenesis. The exploration of endothelial function began in the early 1980s at the start of the epidemic. The study of endothelial function in HIV infection and its modifications by HAART is an exciting new field in clinical research; in this review the available information on cardiovascular diseases associated with HIV infection and its treatment are discussed |
| Disciplines: | Biología, Medicina |
| Keyword: | Inmunología, Virus, Fisiología humana, Sistema cardiovascular, Virus de la inmunodeficiencia humana (VIH), Disfunción endotelial, Moléculas de adhesión, Terapia antirretroviral, Riesgo cardiovascular, Aterosclerosis, Enfermedad coronaria |
| Keyword: | Biology, Medicine, Immunology, Virus, Cardiovascular system, Human physiology, Human immunodeficiency virus (HIV), Endothelial dysfunction, Adhesion molecules, Antiretroviral therapy, Cardiovascular risk, Atherosclerosis, Coronary heart disease |
| Full text: | Texto completo (Ver HTML) |
