A non-randomized comparative study using different doses of acyclovir to prevent herpes simplex reactivation in patients submitted to autologous stem cell transplantation
Título del documento: A non-randomized comparative study using different doses of acyclovir to prevent herpes simplex reactivation in patients submitted to autologous stem cell transplantation
Revista: The brazilian journal of infectious diseases
Base de datos: PERIÓDICA
Número de sistema: 000290967
ISSN: 1413-8670
Autores: 1



2
Instituciones: 1Universidade Federal de Juiz de Fora, Hospital Universitario, Juiz de Fora, Minas Gerais. Brasil
2Universidade Federal do Rio de Janeiro, Hospital Universitario Clementino Fraga Filho, Rio de Janeiro. Brasil
Año:
Periodo: Ago
Volumen: 9
Número: 4
Paginación: 330-335
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Caso clínico
Resumen en inglés The reactivation of Herpes Simplex virus (HSV) occurs in 70% to 80% of patients submitted to autologous stem cell transplantation (ASCT); it increases the severity of chemotherapy-induced mucositis. Therefore, the use of acyclovir in ASCT patients is considered standard practice. However, the minimum dose needed to prevent reactivation is a matter of debate. We compared two doses of acyclovir in a non-randomized fashion in 59 patients submitted to ASCT: 32 patients received a dose of 125 mg/m² IV every six hours and the subsequent 27 patients received a dose of 60 mg/m² IV every six hours. Viral excretion was evaluated through weekly viral culture of oral swabs. Grade 4 mucositis was more frequent in Group 1 (p= 0.03). The reactivation rates in Groups 1 and 2 were 9% and 4%, respectively (p= 0.62, 95% confidence interval -7 - 18). Prophylaxis with reduced doses of intravenous acyclovir seems to be as effective as a higher dose in inhibiting HSV reactivation, with a significant reduction in cost. Prospective randomized studies are needed to confirm our conclusions
Disciplinas: Medicina,
Biología,
Química
Palabras clave: Hematología,
Virus,
Química farmacéutica,
Virus herpes simplex,
Profilaxis,
Acyclovir,
Trasplante homólogo de células madre
Keyword: Medicine,
Biology,
Chemistry,
Hematology,
Virus,
Medicinal chemistry,
Herpes simplex virus,
Prophylaxis,
Acyclovir,
Stem cells transplantation
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