Analysis in the generation of reactive oxygen species through the interaction between the secondary radiation of the compound system (cisplatin and silica nanoparticle) and intracellular water
Document title: Analysis in the generation of reactive oxygen species through the interaction between the secondary radiation of the compound system (cisplatin and silica nanoparticle) and intracellular water
Journal: Revista mexicana de física
Database: PERIÓDICA
System number: 000454032
ISSN: 0035-001X
Authors: 1
2
3
4
5
6
Institutions: 1Instituto Nacional de Investigaciones Nucleares, Departamento de Física, Ocoyoacac, Estado de México. México
2Instituto Nacional de Investigaciones Nucleares, Departamento del Reactor, Ocoyoacac, Estado de México. México
3Instituto Politécnico Nacional, Escuela Superior de Física y Matemáticas, Ciudad de México. México
4Universidad Autónoma de San Luis Potosí, San Luis Potosí. México
5Benemérita Universidad Autónoma de Puebla, Facultad de Ciencias Físico-Matemáticas, Puebla. México
6Instituto Nacional de Investigaciones Nucleares, Departamento de Biología, Ocoyoacac, Estado de México. México
Year:
Season: Nov-Dic
Volumen: 66
Number: 6
Pages: 797-802
Country: México
Language: Inglés
Document type: Artículo
Approach: Analítico, teórico
English abstract Through computer simulations of Monte Carlo (TOPAS-nBio code), the generation of reactive oxygen species will be analyzed when applying external radiation with electrons which energy is 5 keV to the physical system: composite system and intracellular water. This study of the generation of reactive species was focused exclusively on the interaction between secondary radiation from the composite system and intracellular water. This secondary radiation originates from the platinum atom and oxygens (from the composite system) to be the greater influence relative to platinum, which mainly consists of electrons called Auger. In this work, only the influence of these ionizing electrons in intracellular water is considered, leading to the generation of reactive oxygen species. Furthermore, the interaction between the nanoparticle surface and cisplatin was not taken into account
Disciplines: Física y astronomía
Keyword: Física,
Monte Carlo,
Especies reactivas,
Auger
Keyword: Physics,
Monte Carlo,
Reactive species,
Auger
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