Analysis in the generation of reactive oxygen species through the interaction between the secondary radiation of the compound system (cisplatin and silica nanoparticle) and intracellular water
Título del documento: Analysis in the generation of reactive oxygen species through the interaction between the secondary radiation of the compound system (cisplatin and silica nanoparticle) and intracellular water
Revista: Revista mexicana de física
Base de datos: PERIÓDICA
Número de sistema: 000454032
ISSN: 0035-001X
Autors: 1
2
3
4
5
6
Institucions: 1Instituto Nacional de Investigaciones Nucleares, Departamento de Física, Ocoyoacac, Estado de México. México
2Instituto Nacional de Investigaciones Nucleares, Departamento del Reactor, Ocoyoacac, Estado de México. México
3Instituto Politécnico Nacional, Escuela Superior de Física y Matemáticas, Ciudad de México. México
4Universidad Autónoma de San Luis Potosí, San Luis Potosí. México
5Benemérita Universidad Autónoma de Puebla, Facultad de Ciencias Físico-Matemáticas, Puebla. México
6Instituto Nacional de Investigaciones Nucleares, Departamento de Biología, Ocoyoacac, Estado de México. México
Any:
Període: Nov-Dic
Volum: 66
Número: 6
Paginació: 797-802
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, teórico
Resumen en inglés Through computer simulations of Monte Carlo (TOPAS-nBio code), the generation of reactive oxygen species will be analyzed when applying external radiation with electrons which energy is 5 keV to the physical system: composite system and intracellular water. This study of the generation of reactive species was focused exclusively on the interaction between secondary radiation from the composite system and intracellular water. This secondary radiation originates from the platinum atom and oxygens (from the composite system) to be the greater influence relative to platinum, which mainly consists of electrons called Auger. In this work, only the influence of these ionizing electrons in intracellular water is considered, leading to the generation of reactive oxygen species. Furthermore, the interaction between the nanoparticle surface and cisplatin was not taken into account
Disciplines Física y astronomía
Paraules clau: Física,
Monte Carlo,
Especies reactivas,
Auger
Keyword: Physics,
Monte Carlo,
Reactive species,
Auger
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