| Journal: | Revista mexicana de endocrinología metabolismo & nutrición |
| Database: | PERIÓDICA |
| System number: | 000415998 |
| ISSN: | 2339-9643 |
| Authors: | González Ortiz, Manuel1 Martínez Abundis, Esperanza1 Pérez Rubio, Karina G1 Méndez del Villar, Miriam1 Ramírez Rodríguez, Alejandra M1 |
| Institutions: | 1Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco. México |
| Year: | 2016 |
| Season: | Oct-Dic |
| Volumen: | 3 |
| Number: | 4 |
| Pages: | 169-174 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental |
| Spanish abstract | Objetivo: Evaluar el efecto de exenatida semanal sobre el control metabólico y glucémico en pacientes con prediabetes. Métodos: Estudio cuasiexperimental en ocho pacientes con prediabetes sin tratamiento farmacológico. Se les administraron 2 mg de exenatida semanal por vía subcutánea durante 12 semanas. Se hicieron mediciones del control metabólico y glucémico antes y después de la intervención. Se realizó el análisis estadístico con la prueba de rangos de Wilcoxon. Se consideró significativo un valor de p ≤ 0.05. Resultados: Después de la intervención, se observó una disminución del peso corporal (82.5 ± 9.1 vs. 80.6 ± 8.9 kg; p = 0.012), del índice de masa corporal (31.5 ± 3.7 vs. 30.8 ± 3.7 kg/m2 ; p = 0.012), de la circunferencia de cintura (101 ± 8 vs. 97 ± 7 cm; p = 0.008), de la presión arterial sistólica (127 ± 7 vs. 121 ± 7 mmHg; p = 0.021), de la glucosa plasmática en ayuno (6.1 ± 0.4 vs. 5.3 ± 0.9 mmol/l; p = 0.028) y de la hemoglobina glucosilada (A1C) (5.7 ± 0.4 vs. 5.4 ± 0.4%; p = 0.046). Conclusión: La administración de exenatida semanal durante 12 semanas redujo significativamente el peso corporal, el índice de masa corporal, la circunferencia de cintura, la presión arterial sistólica, la glucosa plasmática en ayunas y la HbA1c en pacientes con prediabetes |
| English abstract | Objective: To assess the effect of exenatide once weekly on metabolic and glycemic control in patients with prediabetes. Methods: This was a quasi-experimental study in eight patients with prediabetes without pharmacological treatment. Exenatide (2 mg) once weekly was administered subcutaneously for 12 weeks. Measurements of metabolic and glycemic control were done before and after pharmacological intervention. Differences at baseline and final measurements were tested using Wilcoxon signed-rank test. P ≤ 0.05 was considered significant. Results: After pharmacological intervention, a significant decrease in body weight (82.5 ± 9.1 vs. 80.6 ± 8.9 kg; p = 0.012), body mass index (31.5 ± 3.7 vs. 30.8 ± 3.7 kg/m2 ; p = 0.012), waist circumference (101 ± 8 vs. 97 ± 7 cm; p = 0.017), and systolic blood pressure (127 ± 7 vs. 121 ± 7 mmHg; p = 0.021), as well as fasting plasma glucose (6.1 ± 0.4 vs. 5.3 ± 0.9 mmol/l; p = 0.028) and glycated hemoglobin (A1C) (5.7 ± 0.4 vs. 5.4 ± 0.4%; p = 0.046) were observed. Conclusion: Administration of exenatide once weekly for 12 weeks significantly decreases body weight, body mass index, waist circumference and systolic blood pressure as well as fasting plasma glucose and glycated hemoglobin (A1C) in patients with prediabetes |
| Disciplines: | Medicina |
| Keyword: | Metabolismo y nutrición, Terapéutica y rehabilitación, Exenatida, Control glicémico, Control metabólico, Prediabetes, Efectividad |
| Keyword: | Medicine, Metabolism and nutrition, Therapeutics and rehabilitation, Exenatide, Glycemic control, Metabolic control, Prediabetic state, Effectiveness |
| Full text: | Texto completo (Ver PDF) |
