| Journal: | Revista médica del Hospital General de México |
| Database: | PERIÓDICA |
| System number: | 000439493 |
| ISSN: | 0185-1063 |
| Authors: | Castro, Ana M1 Hernández Peñaloza, Alberto1 Ponce Rosas, Efren R1 Castell Rodríguez, Andrés E1 |
| Institutions: | 1Universidad Nacional Autónoma de México, Facultad de Medicina, Ciudad de México. México |
| Year: | 2019 |
| Season: | Abr-Jun |
| Volumen: | 82 |
| Number: | 2 |
| Pages: | 78-86 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, analítico |
| English abstract | At birth, mammals make the transition from aseptic surroundings to a pathogen-filled environment; hence, the gut is constantly exposed to high antigenic. The mucosal epithelial layer of the gut forms the interface between the external and internal environments of the gastrointestinal tract (GIT) that in newborns allows the passage of nutrients for the maturation of cells in different tissues. In addition to this physiological barrier, an immunological barrier is created and maintained by immune cells located in the gut-associated lymphoid tissue (GALT). The first contact of the pathogens with the host is carried out through the GALT, and it constitutes the most extensive and complex part of the immune system. Aim: The aim of the study was to investigate the development of the intestinal immune response in the suckling rat model. Methods: The location and temporal appearance of the different subsets of B-cells in the GALT and the spleen of suckling and weaning rats were studied histologically using the immunoperoxidase method. Results: The results showed that the number of B-cells of the suckling and weaning rats increases progressively with age; on day 21 when weaning took place, there was an important increase in all B-cells subsets. Mesenteric lymph nodes (MLN) showed the most apparent B-cell subset changes. Interestingly, subpopulations of IgA B-cells and IgG B-cells appear early at 3 days old in NLM unlike Peyer’s patches where these subpopulations appear at 12 and 6 days, respectively, which may indicate that the immune response is originally triggered in intestinal MLN |
| Disciplines: | Medicina |
| Keyword: | Inmunología, Lactancia, Respuesta inmune intestinal, Nódulos linfáticos, Inducción bioquímica, Células B, Modelos animales |
| Keyword: | Immunology, Lactation, Intestinal immune response, Lymph nodes, Biochemical induction, B cells, Animal models |
| Full text: | https://www.hospitalgeneral.mx/frame_esp.php?id=25 |
